… genetic variation in SCN10A, the late sodium current, and alterations in cardiac conduction.
… of common coding variants in the DII–DIII linker that influence cardiac depolarization and …

… We suggest that genetic variants that influence SCN10A-short expression or function dose
dependently affect Na V 1.5-mediated current and conduction velocity in the heart. This was …

… The first variant described as genetic modifier influencing … Genetic variants have been
associated with atrial fibrillation … other genes related to progressive cardiac conduction defects …

… no variants were associated with cardiac conduction disease… that common genetic
variation influences risk and disease … Our results suggest that, first, variability in SCN5A/SCN10A/…

… SCN10A may be one of the major genes responsible for CCSD. … showed genetic variants
associated with CCSD linked to either structurally normal heart diseases or structural heart …

… with gene variants in SCN10A, CACNA1C, or SCN5A. … conduction and to influence cardiac
arrhythmia. Furthermore, … V1073A, rs6795970), 7 which modulates the cardiac conduction …

… predominantly focused on genetic variants in coding regions (… variants contributing to PWD
in genes, such as TTN, SCN10A… the shared genetic components of atrial conduction and AF …

… conduction in BrS patients with rs6795970. In conclusion, … which reflect the process of cardiac
conduction and ventricular … way for SCN10A to generate a BrS phenotype is by influencing …

… fibers of the cardiac conduction system. The allele A of the SCN10A gene polymorphism (…
Chambers JC, et al., Genetic variation in SCN10A influences cardiac conduction. Net. Genet…

… at the SCN10A locus (rs10428132) and near the HEY2 gene (… findings indicate that common
genetic variation can have a … Genetic variation in SCN10A influences cardiac conduction. …