ATAD3B and SKIL polymorphisms associated with antipsychotic-induced QTc interval change in patients with schizophrenia: a genome-wide association study

Z Lu, Y Zhang, H Yan, Y Su, L Guo, Y Liao, T Lu… - Translational …, 2022 - nature.com
study is so far the largest genome-wide association study of antipsychotic-induced QTc interval
… We identified two loci associated with antipsychotic-induced QTc interval change, which …

Effect of GWAS-identified genetic variants on maximum QT interval in patients with schizophrenia receiving antipsychotic agents: a 24-hour Holter ECG study

J Watanabe, N Fukui, Y Suzuki, T Sugai… - Journal of Clinical …, 2017 - journals.lww.com
QT prolongation. Several recent reports have described the use of genome-wide association
studies in … of QT interval variation within the general population. Pfeufer et al 7 analyzed the …

QTc prolongation in short-term treatment of schizophrenia patients: effects of different antipsychotics and genetic factors

I Spellmann, MA Reinhard, D Veverka, P Zill… - European Archives of …, 2018 - Springer
study showed a different potential to affect the QTc interval. … genome-wide association
studies (GWAS) to search for genetic variation mediating antipsychotic-induced QT prolongation in …

Genetic biomarkers of antipsychotic-induced prolongation of the QT interval in patients with schizophrenia

EE Vaiman, NA Shnayder, NM Zhuravlev… - International journal of …, 2022 - mdpi.com
… [60] did not find a significance effect of this SNV in a genome-wide analysis, they did see …
threat that aripiprazole toxicity may provoke QT interval prolongation, albeit without associated …

A molecular pathway analysis informs the genetic risk for arrhythmias during antipsychotic treatment

A Drago, EK Fischer - International clinical psychopharmacology, 2018 - journals.lww.com
… makeup at risk of antipsychotic-induced arrhythmias is the … with a genome-wide level of a
significant association with a QTc … The QT interval is the measure of the milliseconds between …

Genetic factors contribute to medication-induced QT prolongation: a review

T Toba-Oluboka, PG Tibbo, K Dempster, M Alda - Psychiatry Research, 2022 - Elsevier
… This study also found no significant differences in QTc in patients with ABCB1 G2677T/A
genotypes. … Genome-wide association study of antipsychotic-induced QTc interval prolongation

A large genome-wide association study of QT interval length utilizing electronic health records

TJ Hoffmann, M Lu, A Oni-Orisan, C Lee, N Risch… - Genetics, 2022 - academic.oup.com
… of QT interval remains incompletely understood. We conducted a genome-wide association
study … Epidemiology Research on Adult Health and Aging cohort using 448,517 longitudinal …

Common genetic variant risk score is associated with drug-induced QT prolongation and torsade de pointes risk: a pilot study

DG Strauss, J Vicente, L Johannesen, K Blinova… - Circulation, 2017 - Am Heart Assoc
… performed genome-wide association studies (GWASs) of the electrocardiographic QT interval
… to resting QT interval (eg, ≈1 to 3 milliseconds per allele) when considered individually. …

Corrected QT interval prolongation in psychopharmacological treatment and its modulation by genetic variation

F Corponi, C Fabbri, G Boriani, I Diemberger… - …, 2019 - karger.com
… increased risk of antipsychotic-induced QT c prolongation [26-… -analysis of 3 genome-wide
association studies on individuals … -QT syndrome type 2, displaying a suggestive association

Delineating significant genome-wide associations of variants with antipsychotic and antidepressant treatment response: implications for clinical pharmacogenomics

M Koromina, S Koutsilieri, GP Patrinos - Human Genomics, 2020 - Springer
… Over the last decade, genome-wide association studies (GWAS) have widely focused on
tailoring the genetic background of psychiatric diseases [3, 4]. However, most of these findings …