Recent advances in pharmacological and non-pharmacological strategies of cardioprotection

A Caricati-Neto, PR Errante… - International journal of …, 2019 - mdpi.com
… the cellular and molecular mechanisms involved in the cardioprotective response can lead
to … response also can be stimulated by brief cycles of I/R at a remote non-cardiac site (remote …

Targeting the endothelium to achieve cardioprotection

N Herrera-Zelada, U Zuñiga-Cuevas… - Frontiers in …, 2021 - frontiersin.org
… inaccessible sites. Still, its therapeutic role is difficult to study as EPC could not be the only
cell type … , and manipulate exerkines to harness their full power to achieve cardioprotection. …

[HTML][HTML] Harnessing the cardiovascular benefits of exercise: Are Nrf2 activators useful?

B Fasipe, S Li, I Laher - Sports Medicine and Health Science, 2021 - Elsevier
… to modulate endogenous antioxidant systems. Activation of Nrf2 reduces cell damage while
… Metformin can activate AMPK by phosphorylation of the key regulatory site (Thr-172) on the …

Non-invasive strategies for stimulating endogenous repair and regenerative mechanisms in the damaged heart

FC Lewis, SD Kumar, GM Ellison-Hughes - Pharmacological Research, 2018 - Elsevier
… models provides cardioprotection at the level of the cardiomyocyte by increasing cell viability
[52], … Harnessing the potential angiogenic capacity of FGFs for cardiovascular treatment has …

Unravelling the biology of adult cardiac stem cell-derived exosomes to foster endogenous cardiac regeneration and repair

T Mancuso, A Barone, A Salatino, C Molinaro… - International Journal of …, 2020 - mdpi.com
… of the injected cells as cardioprotective and cardio-reparative … and reach target sites far from
their primary release site. These … Harnessing the cellular and molecular basis of this cell-to-…

Harnessing the benefits of endogenous hydrogen sulfide to reduce cardiovascular disease

KM Casin, JW Calvert - Antioxidants, 2021 - mdpi.com
… Together, these enzymes form key nodes to produce and regulate endogenous H 2 S production.
… While few, if any, studies have proven a cardioprotective role for CBS, mutations in this …

Novel therapies targeting cardioprotection and regeneration

V Garrido, E Mendoza-Torres… - Current …, 2017 - ingentaconnect.com
… state of the art regarding novel cardioprotective endogenous peptides, such as … harnessing
their full cardioprotective power. We also explore targeting of exosomes as a cardioprotective

Cardioprotective exercise and pharmacologic interventions as complementary antidotes to cardiovascular disease

JC Quindry, BA Franklin - Exercise and sport sciences reviews, 2018 - journals.lww.com
Endogenous opioids such as enkephalin likely activate one or more … Harnessing the
cardioprotective potential of these, or yet-to-… Endogenous opioid-induced cardioprotection is …

Understanding key mechanisms of exercise-induced cardiac protection to mitigate disease: current knowledge and emerging concepts

BC Bernardo, JYY Ooi, KL Weeks… - Physiological …, 2018 - journals.physiology.org
… The aim of harnessing or exploiting the beneficial effects of … The cardioprotective effects
of Eya2 are considered to be … of the endogenous cellular ROS scavenging mechanisms (ie, …

Protective transcriptional mechanisms in cardiomyocytes and cardiac fibroblasts

CS Brand, JK Lighthouse, MA Trembley - Journal of molecular and cellular …, 2019 - Elsevier
… This review will highlight cardioprotective pathways activated in … of Akt is necessary to
harness its protective capacity. … Thus, resident CFs may serve as an endogenous source of cells …