[HTML][HTML] HLA imputation and its application to genetic and molecular fine-mapping of the MHC region in autoimmune diseases

T Naito, Y Okada - Seminars in immunopathology, 2022 - Springer
… for immune responses and inflammatory pathways [1, 2]. … SLE rather than its tagged
HLA-DRB1*03:01, which had been … , MHC fine-mapping studies have successfully identified the …

Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans

KB Hanscombe, DL Morris, JA Noble… - Human molecular …, 2018 - academic.oup.com
… including HLA-DRB1 * 15:02 in LD with DQA1 * 01 and … as the three HLA alleles share the
same amino acid residue … in the MHC in an AA and EUR population have identified the key …

High-density genetic mapping identifies new susceptibility variants in sarcoidosis phenotypes and shows genomic-driven phenotypic differences

NV Rivera, M Ronninger, K Shchetynsky… - American journal of …, 2016 - atsjournals.org
… A shared overlap between LS and non-LS defined by 17 … a range of autoimmune and
inflammatory diseases (8–11) but … Additionally, because HLA-DRB1*03 plays a strong role in the …

[PDF][PDF] Immune‐array analysis in sporadic inclusion body myositis reveals HLADRB1 amino acid heterogeneity across the myositis spectrum

S Rothwell, RG Cooper, IE Lundberg… - Arthritis & …, 2017 - Wiley Online Library
… by a combination of inflammatory and degenerative changes … there were shared amino acid
positions within HLADRB1 risk … High-density genetic mapping identifies new susceptibility …

HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications

R Busch, S Kollnberger, ED Mellins - Nature Reviews Rheumatology, 2019 - nature.com
… The advent of high-density single-nucleotide polymorphism (… SE of HLA-DRB1 in disease
susceptibility and identified an … The SpAs share associations of varying strength (greatest for …

Association with HLA-DRβ1 position 37 distinguishes juvenile dermatomyositis from adult-onset myositis

CT Deakin, J Bowes, LG Rider, FW Miller… - Human molecular …, 2022 - academic.oup.com
… the most common idiopathic inflammatory myopathy of children. … AH8.1 and HLA-DRB1 *
03:01, HLA-C * 02:02 and identify a … While JDM and adult-onset dermatomyositis (DM) share

Transethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals not only shared but also ethnicity-specific disease associations

F Degenhardt, G Mayr, M Wendorff… - Human molecular …, 2021 - academic.oup.com
Inflammatory bowel disease (IBD) is a chronic inflammatory … Notably, we identified DRB1 *
01:03, which was identified as … In the analysis of peptide-binding preferences for HLA-DRB1

New insights into the understanding of MHC associations with immune‐mediated disorders

S Caillat‐Zucman - Hla, 2017 - Wiley Online Library
… region has been improved by high density array-based … peanut allergy and HLA-DRB1*08
and DQB1*06:03 alleles 24. … s) found at sites of inflammation in AS to cytotoxic T lymphocytes…

[HTML][HTML] The lupus susceptibility allele DRB1*03:01 encodes a disease-driving epitope

B Miglioranza Scavuzzi, V van Drongelen… - Communications …, 2022 - nature.com
… The HLA-DRB1*03:01 allele is a … identified SLE-relevant terms that were shared between
65-79*LE-treated human and mouse macrophages, including terms pertaining to inflammatory

Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic …

S Rothwell, RG Cooper, IE Lundberg… - Annals of the …, 2016 - ard.bmj.com
… were identified. HLA imputation confirmed that alleles HLA-DRB1*03:01 and HLA-B*08:01
While there is evidence that risk loci may be shared across populations, such as STAT4 and …