… Paraffin section of a cerebral ganglion from Aplysia limacina immunostained with anti-d-…
immunohistochemical staining with anti-d-Asp antibodies in order to visualize d-Asp localization …

… Moreover, immunohistochemical studies have shown that in the telencephalon and … In
the animal brain, D-aspartate has been detected in hippocampal and frontal cortex neurons, …

… Subsequently, d-amino acids were found to be present in human brain tissue, teeth, and
the eye lens [8,9,10,11,12]. Over the past three decades, more research focusing on …

… , D-amino acids that are surplus to immediate utilization are degraded by D-amino acid
oxidases (DAAOs), with the resulting keto acid … –brain barrier implies that these D-amino acids …

… mechanism is known to be degraded by d-amino acid oxidase (DAO) expressed at highest
… (validated with immunoprecipitation and immunocytochemistry in Supplementary Fig. S1). …

… slices using glycine oxidase and d-amino acid oxidase in the … their expression using
immunocytochemistry on primary … l-serine indicated that brain astrocytes stained intensely with …

… Because of these reasons much effort has been invested to discover DAAO inhibitors that
could potentially increase the levels of d-amino acids in the brain, and thus enhance NMDA …

… d-serine is metabolized by D-amino acid oxidase (DAAO, EC 1.4.3.3), present in the
kidneys, liver, and brain. One of its metabolites, hydrogen peroxide (H 2 O 2 ), causes oxidative …

… (Aβ) deposition in the brain is one of the main pathological … The silver staining and
immunohistochemical methods were … D-amino acid oxidase (DAAO) was purchased from Yuanye …

… -serine level by SR, D-amino acid oxidase (DAAO) is another … Experiments in rat brain cell
cultures showed that neuronal D… by RT-PCR and immunohistochemistry. The results showed …