d-Aspartate, an Atypical Amino Acid with NMDA Receptor Agonist Features: Involvement in Schizophrenia

F Errico, A Usiello - The NMDA Receptors, 2017 - Springer
… d-Asp in mammalian brain homogenates has shown that this d-amino acidrat brain, two
different immunohistochemical studies have investigated the presence of d-Asp in the rat brain

d-Alanine: Distribution, origin, physiological relevance, and implications in disease

CJ Lee, TA Qiu, JV Sweedler - … et Biophysica Acta (BBA)-Proteins and …, 2020 - Elsevier
… Enzymatic d-Ala digestion using d-amino acid oxidase (… further characterized using
immunohistochemistry with an anti-d-… < 10 nmol/g wet tissue in brain regions and was especially …

[HTML][HTML] Species-specific neuronal localization of kynurenine aminotransferase-2 in the mouse cerebellum

E Balog, G Jenei, L Gellért, E Ono, L Vécsei… - Neurochemistry …, 2021 - Elsevier
… may be produced from D-kynurenine by D-amino acid oxidase and by direct transformation
of … We performed immunohistochemistry on mouse brain sections and immunocytochemistry

The rise and fall of the d-serine-mediated gliotransmission hypothesis

H Wolosker, DT Balu, JT Coyle - Trends in neurosciences, 2016 - cell.com
… slices with purified d-amino acid oxidase (DAO) to degrade d-serine or purified glycine oxidase
(GO… Robust neuronal SR staining in rat cerebral cortex (A) and hippocampal CA1 (B). SR …

Effect of risperidone on plasma d-serine concentration in rats post-administered with d-serine

M Onozato, H Nakazawa, H Hakariya, M Shishikura… - Life sciences, 2016 - Elsevier
… On the other hand, d-Ser levels in vivo can be increased by suppressing its metabolism
by d-amino acid oxidase (DAO). Alt et al. reported that oral co-administration of 5-chloro-benzo[d]…

[HTML][HTML] Decreased d-Serine levels prevent retinal ganglion cell apoptosis in a glaucomatous animal model

X Zhang, R Zhang, X Zhou, J Wu - … Ophthalmology & Visual …, 2018 - jov.arvojournals.org
d-Amino acid oxidase (DAAO) treatment significantly … d-Serine, an unusual amino acid
synthesized in the brain by … for SR and performed immunohistochemistry analysis. We noted an …

D-Serine and glycine differentially control neurotransmission during visual cortex critical period

CNJ Meunier, G Dallérac, N Le Roux, S Sacchi… - PLoS …, 2016 - journals.plos.org
… the enzymatic scavenger d-amino acid oxidase causes NMDAR… by cervical dislocation to
excise brain tissues for experiments … P28 rats were killed by cervical dislocation and their brains

The impact of aged microglia on d-serine-regulated glutamatergic transmission

S Beltrán-Castillo, R von Bernhardi… - Factors Affecting …, 2021 - Elsevier
… to restore the brain homeostasis. The … d-amino acid oxidase (RgDAAO) enzyme that degrades
endogenous extracellular d-serine, but it is not affected by Bacillus subtilis glycine oxidase

[PDF][PDF] D-Serine and its important role in the endocrine and central nervous systems

KD Schnackerz - researchgate.net
… [14] and is selectively degraded by both SR and the peroxisomal D-amino acid oxidase (DAAO, …
Previous immunohistochemical analysis of SR expression in rat brain did not detect its …

New evidence on the role of d-aspartate metabolism in regulating brain and endocrine system physiology: From preclinical observations to clinical applications

A Usiello, MM Di Fiore, A De Rosa, S Falvo… - International Journal of …, 2020 - mdpi.com
… of this D-amino acid are drastically reduced at adulthood (0.008 μmol/g) [9,10,25,26]. In
line with this finding, immunohistochemical studies in the rat embryonic brain revealed that D-…