The role of serine racemase in the pathophysiology of brain disorders

JT Coyle, DT Balu - Advances in pharmacology, 2018 - Elsevier
… to localize it immunocytochemically. Our laboratory has focused on the role of d-serine in …
by d-amino acid oxidase (DAAO). Inflammatory insults such as traumatic brain injury cause the …

Homeostasis of Free d-Aspartate in Mammalian Cells

H Homma, M Katane - D-Amino Acids: Physiology, Metabolism, and …, 2016 - Springer
… , immunocytochemical staining, and enzymatic assays based on d-Asp-specific oxidase
reactivity, showed that rat … Enzyme histochemical analysis of rat brain tissues revealed that DDO …

Chiral amino acid metabolomics for novel biomarker screening in the prognosis of chronic kidney disease

T Kimura, K Hamase, Y Miyoshi, R Yamamoto… - Scientific reports, 2016 - nature.com
brain 7,8,9,10,11,12,13 . Several reports suggest the potential relationships between the
amounts of D-amino acids … due to decreased activity of D-amino acid oxidase (DAO), but not by …

Multi-dimensional high-performance liquid chromatographic determination of chiral amino acids and related compounds in real world samples

C ISHII, A FURUSHO, CL HSIEH, K HAMASE - Chromatography, 2020 - jstage.jst.go.jp
brain is extremely low, the presence of D-Pro is confirmed by the enzymatic degradation by
D-amino acid oxidase (… For the immunohistochemical staining, a mouse monoclonal antibody …

Methodological advances for the measurement of the D-amino acids across the metazoa: From mollusks to man

AV Patel - 2018 - ideals.illinois.edu
… in rat and mouse pancreas.Additionally, immunohistochemical visualization showed co-localization
of D-… from Aplysia californica,22 localization of active D-AAO in rat brain slices,9 and …

Serine racemase expression by striatal neurons

S Takagi, MD Puhl, T Anderson, DT Balu… - Cellular and molecular …, 2022 - Springer
… These immunocytochemical findings were confirmed by conditionally … Antiserum (goat
polyclonal) against d-amino acid oxidase (… input from the cerebral cortex and other structures. The …

Persistent elevation of D-Aspartate enhances NMDA receptor-mediated responses in mouse substantia nigra pars compacta dopamine neurons

P Krashia, A Ledonne, A Nobili, A Cordella, F Errico… - …, 2016 - Elsevier
… aspartate oxidase gene (Ddo −/− ) knock-out mice that show a concomitant increase in brain
… (2014) reported increased burst firing of midbrain DAergic neurons in D-amino acid oxidase

Subsaturation of the N‐methyl‐D‐aspartate receptor glycine site allows the regulation of bursting activity in juvenile rat nigral dopamine neurons

G Destreel, V Seutin, D Engel - European Journal of …, 2019 - Wiley Online Library
… Acute brain slices were prepared from postnatal 16- to 26-… For TH immunohistochemistry,
slices were incubated with a … vivo in animals devoid of D-amino acid oxidase (Schweimer et al., …

d-Amino Acids and Classical Neurotransmitters in Healthy and Type 2 Diabetes-Affected Human Pancreatic Islets of Langerhans

CJ Lee, JH Schnieders, SS Rubakhin, AV Patel, C Liu… - Metabolites, 2022 - mdpi.com
… in human pancreatic islets through immunohistochemical staining or the secretion from islets…
of other less common cell–cell signaling molecules—the d-amino acids (d-AAs) [14]. d-AAs, …

Design and synthesis of D-amino acid oxidase inhibitors

B Szilágyi - 2019 - search.proquest.com
D-amino acid oxidase enzyme and administration of D-serine may indirectly alleviate negative
and cognitive symptoms. In this chapter I present the role of D-amino acid oxidasebrain