Analysis of D-amino acids secreted from murine islets of Langerhans using Marfey's reagent and reversed phase LC-MS/MS

EO Ogunkunle, JJ Davis, EL Skinner… - … of Chromatography B, 2023 - Elsevier
D-amino acids (D-AAs) have been found in various tissues including the brain [1], [2], [3], [4],
kidney [2], [3], [4], and pancreas [2], [3], [4], [5], [6] and have been implicated in several …

Evaluation of Individual Variation of d-Amino Acids in Human Plasma by a Two-Dimensional LC–MS/MS System and Application to the Early Diagnosis of Chronic …

C Ishii, T Akita, T Kimura, S Sakai, M Mita… - Analytical …, 2024 - ACS Publications
… of the intrinsic d-amino acids are around 1% or … d-amino acids in clinical samples. Therefore,
for the screening of biomarker candidates focusing on various trace levels of d-amino acids, …

D-Amino Acids are Signaling Agents Under Stress, that Broadly Impact Preventive Medicine

EBI Monselise - 2019 - preprints.org
D-amino acids have also clarified the localization and functions of D-amino acids in the
CNS … endocrine systems, and the physiological functions of these D-amino acids are being …

Relations between Glucose and d-Amino Acids in the Modulation of Biochemical and Functional Properties of Rodent Islets of Langerhans

CJ Lee, DK Lee, IA Wei, TA Qiu, SS Rubakhin… - ACS …, 2023 - ACS Publications
… The cell-to-cell signaling role of d-amino acids (d-AAs) in the mammalian endocrine
system, particularly in the islets of Langerhans, has drawn growing interest for their potential …

Eukaryotic d-Serine Dehydratase

T Ito, T Yoshimura, T Ishida, H Tanaka - D-Amino Acids: Physiology …, 2016 - Springer
d-Amino acid oxidase (DAO) is the only mammalian enzyme … rat brains, the localization of
dao is reciprocal to that of d-serine (Horiike et al. 1987), suggesting that, in mammalian brains

Lack of Effect of Sodium Benzoate at Reported Clinical Therapeutic Concentration on d-Alanine Metabolism in Dogs

M Popiolek, B Tierney, SJ Steyn… - ACS Chemical …, 2018 - ACS Publications
d-Amino acid oxidase (DAAO) is a flavoenzyme oxidase whose main function is degradation
of certain d-amino acids … A rodent study where brain d-amino acid levels were enhanced …

ASC transporters mediate D-serine transport into astrocytes adjacent to synapses in the mouse brain

KS Krishnan, B Billups - Biomolecules, 2023 - mdpi.com
… One pathway is via D-amino acid oxidase (DAAO), which catalyses the oxidative … As there
is strong DAAO expression and activity in Bergmann glia, it is likely to catalyse the oxidation of …

d-Serine and the Pathophysiology of Schizophrenia

JT Coyle - D-Amino Acids: Physiology, Metabolism, and …, 2016 - Springer
… and d-amino acid oxidase have been found in schizophrenia. Genetically silencing the SR
gene (SR−/−) in mice causes an 85 % reduction of d-serine in the brainImmunocytochemical

D-serine contributes to seizure development via ERK signaling

T Ma, Y Wu, B Chen, W Zhang, L Jin, C Shen… - Frontiers in …, 2019 - frontiersin.org
… In contrast, D-amino acid oxidase inhibitor 5-chlorobenzo[d]… 1.74 years, who suffered traumatic
brain injury were included as … For immunohistochemistry analysis, rats were anesthetized …

Neuromodulatory Activity of d-Aspartate in Mammals

F Errico, A Usiello - D-Amino Acids: Physiology, Metabolism, and …, 2016 - Springer
… In the rat brain, two different immunohistochemical studies have investigated the presence
… its localization in the developing brain imply that the endogenous levels of this d-amino acid