… limited in size, our results inform and support further evaluation of prefusion-stabilized HIV-1
envelope trimers … focused on the exposed glycan-free base of the soluble Env trimer. This …

… aromatic residues to reduce V3 exposure (A316W, A319Y), … SOSIP trimers also induced
strong non-neutralizing antibody … To further improve the immunogenicity of Env trimers, we can …

… BG505 SOSIP.664 trimers have already been further stabilized by … state and thereby reduces
the exposure of non-NAb epitopes ( … with reduced exposure of non-neutralizing epitopes. …

… with further reduced V3 exposure, we sought to engineer mutations that stabilize the native-…
We investigated the immunogenicity of three 327c native-like trimers in rabbits: 327c SOSIP.…

… Stabilizing HIV-1 Env trimers in the closed pre-fusion state reduces their propensity to …
this may be important for reducing their induction of immunodominant non-NAb responses. …

… The HIV-1 envelope (Env) spike is a trimer of gp120/gp41 … We locked the HIV-1 Env trimer
in a pre-fusion configuration, … to soluble trimers and native gp160 from different HIV-1 clades. …

… with reduced exposure of non-neutralizing epitopes. Cell. … -like HIV-1 envelope trimers to
silence nonneutralizing epitopes and … and immunogenicity of a stabilized HIV-1 envelope trimer …

… Taken together, we conclude that Env trimer stabilization tends to reduce exposure of V3 …
Immunogenicity of stabilized HIV-1 envelope trimers with reduced exposure of non-neutralizing …

… immunogenicity can be diminished, but not abolished, by reducing the conformational flexibility
of trimers … Here, we further modified these trimer designs by introducing leucine residues …

… To limit the exposure of rare isolate-specific antigenic … trimer including, but not limited to,
ones that target the trimer apex… ) 2G12 and PGT145 and non-neutralizing antibodies (non-NAbs) …