Oral absorption basics: pathways and physicochemical and biological factors affecting absorption

L Zhu, L Lu, S Wang, J Wu, J Shi, T Yan, C Xie… - Developing solid oral …, 2017 - Elsevier
… of patients could also significantly affect the absorption of drugs. … absorption, metabolism,
and elimination pathways of drugs, as well as the physicochemical and physiological factors

[HTML][HTML] Impact of gastrointestinal physiology on drug absorption in special populations––An UNGAP review

C Stillhart, K Vučićević, P Augustijns, AW Basit… - … of Pharmaceutical …, 2020 - Elsevier
… The release and absorption profile of an oral medication is influenced by the physicochemical
properties of the drug and its formulation, as well as by the anatomy and physiology of the …

Physicochemical characterization of biopharmaceuticals

MK Parr, O Montacir, H Montacir - … pharmaceutical and biomedical analysis, 2016 - Elsevier
… strongly impact the final biological. Thus, quality assurance of biopharmaceuticals results
in … The molecular weight of the intact molecule is the first physical parameter to be analyzed …

In vitro oral drug permeation models: the importance of taking physiological and physico-chemical factors into consideration

R Joubert, JD Steyn, HJ Heystek… - Expert opinion on …, 2017 - Taylor & Francis
… of a generic product depending on the biopharmaceutical classification of the specific drug.
However, … Furthermore, these physiological factors that can affect drug absorption from the …

[HTML][HTML] Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review

Z Vinarov, M Abdallah, JAG Agundez… - … of Pharmaceutical …, 2021 - Elsevier
… The absorption of oral drugs is frequently plagued by significant variability with … consequences.
The source of variability can be traced back to interindividual variability in physiology, …

Revising pharmacokinetics of oral drug absorption: I models based on biopharmaceutical/physiological and finite absorption time concepts

P Macheras, P Chryssafidis - Pharmaceutical research, 2020 - Springer
… on physiological aspects of the gastrointestinal (GI) tract [6] such as (a) drug/formulation-dependent
factors— drug physicochemical … no first pass effect, ie fraction of dose absorbed = …

Biopharmaceutics applications of physiologically based pharmacokinetic absorption modeling and simulation in regulatory submissions to the US Food and Drug …

F Wu, H Shah, M Li, P Duan, P Zhao, S Suarez… - The AAPS Journal, 2021 - Springer
biopharmaceutics applications) integrates gastrointestinal (GI) tract anatomical and physiological
aspects with drug physicochemical … of effect of elevating pH on the oral absorption of …

Assessment of biopharmaceutical properties

M Ashford - Aulton's Pharmaceutics E-Book: The Design and …, 2017 - books.google.com
… drug absorption. … effect of physicochemical and dosage form factors such as the influence
of salts and particle size on the predicted plasma profile and the effect of physiological factors

Physiologic Factors Related to Drug Absorption

PC Acharya, C Fernandes, S Mallik, B Mishra… - Dosage form design …, 2018 - Elsevier
… the physicochemical, physiological, and pharmaceutical factors to … This chapter focuses on
various physiological constraints … the physiological barriers that can affect the drug absorption

Biopharmaceutical understanding of excipient variability on drug apparent solubility based on drug physicochemical properties. Case study: Superdisintegrants

P Zarmpi, T Flanagan, E Meehan, J Mann, N Fotaki - The AAPS Journal, 2020 - Springer
affect the biopharmaceutical profile of drugs with potential implications on drug absorption
(2,3… of excipient in the total volume of the physical mixture as per the poorly soluble drugs. The …