Implications of SARS-Cov-2 infection on eNOS and iNOS activity: Consequences for the respiratory and vascular systems
LMF Guimaraes, CVT Rossini, C Lameu - Nitric oxide, 2021 - Elsevier
Symptoms of COVID-19 range from asymptomatic/mild symptoms to severe illness and
death, consequence of an excessive inflammatory process triggered by SARS-CoV-2
infection. The diffuse inflammation leads to endothelium dysfunction in pulmonary blood
vessels, uncoupling eNOS activity, lowering NO production, causing pulmonary
physiological alterations and coagulopathy. On the other hand, iNOS activity is increased,
which may be advantageous for host defense, once NO plays antiviral effects. However …
death, consequence of an excessive inflammatory process triggered by SARS-CoV-2
infection. The diffuse inflammation leads to endothelium dysfunction in pulmonary blood
vessels, uncoupling eNOS activity, lowering NO production, causing pulmonary
physiological alterations and coagulopathy. On the other hand, iNOS activity is increased,
which may be advantageous for host defense, once NO plays antiviral effects. However …
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