severe COVID-19 cases. Using single-cell RNA sequencing of bronchoalveolar lavage fluid,
this preprint study from Liao et al. found that the depletion of tissue-resident alveolar
macrophages and the accumulation of monocyte-derived inflammatory macrophages
associate with disease severity. Inflammatory macrophages adopted interferon-signalling
and monocyte-recruiting chemokine programmes that may drive ARDS. Increased clonal …