Electron cryo-microscopy structure of Ebola virus nucleoprotein reveals a mechanism for nucleocapsid-like assembly

Z Su, C Wu, L Shi, P Luthra, GD Pintilie, B Johnson… - Cell, 2018 - cell.com
… scaffold for viral RNA synthesis. However, molecular insights into the NC assembly process
… Using a hybrid approach, we characterized the NC-like assembly of eNP, identified novel …

Structure and assembly of the Ebola virus nucleocapsid

W Wan, L Kolesnikova, M Clarke, A Koehler, T Noda… - Nature, 2017 - nature.com
nucleocapsid acts as a scaffold for virus assembly and as a template for genome transcription
and replication. Insights into … fitting search using available crystal structures of VP24, the …

Structural basis of Ebola virus nucleocapsid assembly and functions

Y Fujita-Fujiharu, S Hu, A Hirabayashi, Y Takamatsu… - bioRxiv, 2024 - biorxiv.org
… Compared to our two VP24 models, a previously reported crystal structure of the … Insight
into the Ebola virus nucleocapsid assembly mechanism: crystal 346 structure of Ebola virus

[HTML][HTML] Molecular determinants of Ebola nucleocapsid stability from molecular dynamics simulations

C Xu, N Katyal, T Nesterova, JR Perilla - The Journal of Chemical …, 2020 - pubs.aip.org
… defense mechanisms and form a minimal functional unit for viral … EBOV nucleocapsid helical
assembly and provide insights into … that control the stability of the Ebola virus nucleocapsid. …

In vitro assembly of Ebola virus nucleocapsid-like complex expressed in E. coli

R Peng, T Zhu, BO Oladejo, AM Musyoki, Y Cui… - Protein & …, 2016 - academic.oup.com
… were obtained from monomeric core proteins that unable to either assemble into NLC or
bind RNA. Therefore, the detailed molecular mechanism of nucleocapsid assembly still …

Cryo-EM structure of the Ebola virus nucleoprotein–RNA complex at 3.6 Å resolution

Y Sugita, H Matsunami, Y Kawaoka, T Noda, M Wolf - Nature, 2018 - nature.com
… Our structure reveals how the Ebola virus nucleocapsid core … nucleocapsid assembly and
highlights key structural features that … First, a previously reported crystal structure of Ebola NP …

Filovirus helical nucleocapsid structures

S Hu, T Noda - Microscopy, 2023 - academic.oup.com
… of the Ebola virus and Marburg virus nucleocapsid structures, … -EM has provided insights
into the detailed structure of EBOV … mechanism: crystal structure of Ebola virus nucleoprotein …

A simulation investigation on interaction mechanism between Ebola nucleoprotein and VP35 peptide

JN Ding, YJ Zhang, H Zhong, CC Ao… - … Structure and Dynamics, 2018 - Taylor & Francis
… binding mechanisms than do hints from the static crystal structure … In order to have an
insight into the binding mechanism at an … Structural dissection of Ebola virus and its assembly

Intracellular Ebola Virus nucleocapsid assembly revealed by in situ cryo-electron tomography.

R Watanabe, D Zyla, D Parekh, C Hong, Y Jones… - bioRxiv, 2023 - biorxiv.org
nucleocapsid assembly and a condensation mechanism that … Therefore, we had no structural
insights into how Ebola virus … , we could fit the crystal structure of VP35 amino acids 81-340, …

Structure of the Ebola virus polymerase complex

B Yuan, Q Peng, J Cheng, M Wang, J Zhong, J Qi… - Nature, 2022 - nature.com
nucleocapsid formation by binding the monomeric NP to prevent premature and non-specific
assembly … The density for VP35 C-termini was well fitted with the reported crystal structure (…