… failing to provide a holistic understanding of ASD pathology. In … to integrate higher-order
functional genomic information and … core of our molecular pathway networks mediating several …

… ’ relevance within the intracellular circuits, the strength of the … in non-neuronal specific
signaling pathways, which are also … resequencing of these functional genomic regions has been …

Autism Spectrum Disorders (ASDs) are a group of clinically and etiologically heterogeneous
neurodevelopmental disorders that are estimated to affect 1–2% of the population in the …

… genome-wide analysis to identify the rare single nucleotide variants (SNVs) that occur in
non-coding regions and determined the regulatory function … and synaptic signaling pathways. …

… analyses that focused on autism 12,13,14,15,16,17,18,19,20 demonstrate the promise of
functional genomics … We recently built an integrative gene network that serves as a robust …

… risk genes into specific co-expression modules. Co-expression network analysis facilitates
the … with known ASD risk genes, affected molecular pathways and at-risk developmental time …

… and assembled into functionally distinct circuits and regions (1–… Putative promoters and
enhancers (H3K27ac peaks) specific … score regression analysis from GWASs for autism spectrum …

… higher than expected comorbidity with autism. It is critical … molecular pathways that influence
the development of neurons and synapses that, in turn, affect brain connectivity and function …

… and variety of signaling pathway, and four core modules were identified in which genes
significantly involved in ASD symptoms-associated biological processes and pathways. Then, …

… by activation of the Wnt signaling pathway [75] and is also related to dopaminergic neuron
differentiation [76]. The Wnt pathway is one of the main pathways that have been associated …