Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets

Y Li, JA Estep, FV Karginov - Journal of molecular biology, 2018 - Elsevier
… interactions between HuR, a ubiquitous RNA-binding protein, … In summary, the available
CLIP data indicate that HuR … In summary, we present an integrated approach to identify HuR–…

Post-transcriptional regulation of Pabpn1 by the RNA binding protein HuR

BL Phillips, A Banerjee, BJ Sanchez… - Nucleic Acids …, 2018 - academic.oup.com
… Furthermore, a recent study showed that a circular RNA, CircPABPN1, generated from
PABPN1 pre-mRNA binds and sequesters HuR in HeLa cells (83). This study also demonstrated …

The RNA-binding protein HuR is a negative regulator in adipogenesis

DTC Siang, YC Lim, AMM Kyaw, KN Win… - Nature …, 2020 - nature.com
… As expected, HuR targets identified in our RIP-seq analysis showed … 9a), indicating an
unlikelihood that HuR controls its own … To further explore the regulation of HuR expression during …

The RNA-binding protein HuR is required for maintenance of the germinal centre response

IC Osma-Garcia, D Capitan-Sobrino… - Nature …, 2021 - nature.com
… hCD2 and HuR expression in HuR fl/fl AID Cre mice showed … to understand further the
regulation of HuR in GC B cells. To … fl/fl AID Cre GC B cells as we did not detect reads mapped to …

Global approaches in studying RNA-binding protein interaction networks

EL Sternburg, FV Karginov - Trends in biochemical sciences, 2020 - cell.com
… complex regulatory outcomes. Transcriptome-wide methods and integrative analyses have
… We illustrate the methods with specific examples and distill some of the regulatory principles …

[HTML][HTML] Post-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1

JR Poganik, MJC Long, MT Disare, X Liu… - The FASEB …, 2019 - ncbi.nlm.nih.gov
… Our data showed that HuR enhances Nrf2-mRNA maturation … Trimmed reads were mapped
to rRNA sequences with bowtie2 … Bands of interest were integrated and normalized to the …

The RNA-binding protein HuR posttranscriptionally regulates the protumorigenic activator YAP1 in pancreatic ductal adenocarcinoma

SZ Brown, GA McCarthy, JR Carroll… - … and cellular biology, 2022 - Am Soc Microbiol
… , we found that silencing of HuR had no impact on pre-mRNA levels ( Fig. … Together, these
data suggest that HuR regulates YAP1 … The Oncomine web platform is an integrated database …

Modeling the combined effect of RNA-binding proteins and microRNAs in post-transcriptional regulation

S HafezQorani, A Lafzi, RG de Bruin… - Nucleic acids …, 2016 - academic.oup.com
… In this study, we mapped the RBP and miRNA target sites on human 3′UTRs by combining
… Our results on HuR and PUM1(2) knockdown datasets indicate that the presence of multiple…

RNA-binding protein HuR and the members of the miR-200 family play an unconventional role in the regulation of c-Jun mRNA

G Del Vecchio, F De Vito, SJ Saunders, A Risi… - Rna, 2016 - rnajournal.cshlp.org
… is controlled at multiple levels: pre-mRNA splicing and maturation, … The luciferase assay
reveals that after the depletion of HuR our … This result suggests an involvement of HuR in the …

RNA-binding protein HuR regulates nuclear import of protein

W Zhang, AC Vreeland, N Noy - Journal of cell science, 2016 - journals.biologists.com
… CRABP2 binds to HuR and dramatically increases its RNA-binding affinity. Consequently…
Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA