… , the Z protein is both necessary and sufficient for driving the … Z proteins, with the exception
of the Tacaribe virus Z protein, … , decreased virus-like particle (VLP) release occurs following …

… of virus-like particles and the release of infectious progeny … Z protein in the absence of
other viral proteins is sufficient for … each cellular protein for the indicated virus Z protein (retrieved …

… viral life cycle. Here we present the dodecameric form of Lassa virus Z and demonstrate that
Z … This structure and that of monomeric Z now provide a pair of critical templates by which …

… , and it is the main viral antigen used for the design of an … virus-like particles (VLPs)
expressing GP from the prototypic LASV strain Josiah in a native-like conformation as the sole viral …

… , chiefly Lassa virus (LASV), cause hemorrhagic fever disease … the NW virus proteins, the
OW virus Z proteins interact with … (LCMV) are sufficient for efficient transcription and replication …

… RNA polymerization required manganese rather than magnesium ions, was independent
of nucleotide primers, and was inhibited by viral Z protein. Maximum activity was mediated by …

… Here, we show that Z proteins of diverse … Z proteins of four known LCMV strains can also
inhibit hRIG-I at variable degrees of efficiency. Collectively, our results confirm that Z proteins of …

… in autophagosome accumulation that promotes the budding of LASV virus-like particles (VLPs).
Inhibition of LASV-Z-induced autophagosome accumulation blocks the LASV VLP …

… , in which DNA sequences encoding both viral Z proteins and candidate host interactors
are … Overall, we hypothesize that, although basal autophagy is sufficient to sustain LASV …

… Both Lassa and Ebola encode matrix proteins that play key roles in … the Lassa Z or Ebola
VP40 matrix protein alone is sufficient to generate the formation of Z or VP40 virus-like particles (…