… detail, perturbations in cholesterol homeostasis on a cellular … behaviors that may contribute
to plaque development. Thus, … miR-33 and miR-27b may also indirectly regulate cholesterol …

… –knockout mice are predisposed to the development of obesity and metabolic dysfunction,
we sought to determine the extent to which hepatic miR-33 contributes to this phenotype. …

… of lipid metabolism is essential for the maintenance of cholesterol homeostasis. Over
recent decades, miRNAs have been proposed as central regulators of lipid and lipoprotein …

… miR-33 targeting of autophagy contributes to its regulation of cholesterol homeostasis and …
into the mechanisms by which miR-33 regulates cellular cholesterol homeostasis, and how its …

… of macrophage cholesterol efflux and HDL biogenesis, miR-33 is a … miR-33 increases HDL
levels and reduces plaque burden. However, important questions remain about how miR-33 …

… effects on macrophage cholesterol homeostasis and to avoid adverse effects on cardiac
dysfunction, effective strategies such as cell- or tissue-specific targeting of miR-33 may need to …

… A key protein involved in this disorder is the transmembrane protein ABCA1, which is
responsible for cholesterol homeostasis and plasma membrane remodelling. This transporter …

… roles of miR-33 in the regulation of lipid homeostasis suggest potential therapeutic applications
of miR-33 … This study shows negative regulation of the FTO gene by miR-33 in chicken. …

… to hyperlipidemia or CVD through dysregulation of lipid biosynthesis and cholesterol …
miR-33 antagonism remarkably lowers VLDL and increases HDL through modulation of miR-33 …

… target of miR-33 responsible for its ability to regulate macrophage cholesterol efflux and …
Although miR-33 like many microRNAs can mediate complex physiological effects in vivo, …