Structure of the human secretin receptor coupled to an engineered heterotrimeric G protein

S Fukuhara, K Kobayashi, T Kusakizako, W Iida… - Biochemical and …, 2020 - Elsevier
Secretin is a gastrointestinal hormone that exerts multiple physiological functions via … of
the secretin receptor (SECR). SECR belongs to the class B G-protein-coupled receptors and is …

[PDF][PDF] Secretin Receptor

M PAGE - pancreapedia.org
… hold special places in history, with secretin representing the … secretion in 1902 (1), and with
the secretin receptor cloned by T. … receptor and giving rise to this new and important receptor

Secretin receptor as a target in gastrointestinal cancer: expression analysis and ligand development

A Klussmeier, S Aurich, L Niederstadt, B Wiedenmann… - Biomedicines, 2022 - mdpi.com
… overexpression and the use of optimized tracer molecules. In this study, the expression of
secretin receptor (SCTR) was characterized by immunohistochemistry of paraffin-embedded …

Secretin amino-terminal structure-activity relationships and complementary mutagenesis at the site of docking to the secretin receptor

JE Milburn, KG Harikumar, SJ Piper, S Raval… - Molecular …, 2022 - ASPET
… This was typically used to determine the differences of binding and biologic activity of secretin
analog peptides relative to that of natural secretin at a particular secretin receptor construct…

[HTML][HTML] Activation of supraoptic oxytocin neurons by secretin facilitates social recognition

Y Takayanagi, M Yoshida, A Takashima, K Takanami… - Biological …, 2017 - Elsevier
… study, effects of secretin were blocked by deficiency of the secretin receptor, and oxytocin …
of secretin observed in the present study was mediated by the secretin receptor expressed in …

Multiplexed analysis of the secretin-like GPCR-RAMP interactome

E Lorenzen, T Dodig-Crnković, IB Kotliar, E Pin… - Science …, 2019 - science.org
… The human secretin-like GPCR and ADGRF5 cDNAs encoded the 23–amino acid
residue 5-hydroxytryptamine receptor 3a receptor (5-HT3a) signal sequence (…

[HTML][HTML] Secretin-activated brown fat mediates prandial thermogenesis to induce satiation

Y Li, K Schnabl, SM Gabler, M Willershäuser, J Reber… - Cell, 2018 - cell.com
gene expression of gut hormone receptorsreceptor genes in iBAT, the secretin receptor
(Sctr) stood out with the highest transcript abundance compared to other gut hormone receptors (…

Molecular cloning of feline resistin and the expression of resistin, leptin and adiponectin in the adipose tissue of normal and obese cats

S Takashima, N Nishii, A Kato, T Matsubara… - Journal of Veterinary …, 2016 - jstage.jst.go.jp
… Thus, we report the molecular cloning of the feline resistin gene. In addition, we evaluate
the change in the transcription levels of resistin with obesity in subcutaneous and visceral …

Secretin: a hormone for HCO3 homeostasis

P Berg, SL Svendsen, N Ayasse, MV Sorensen… - … -European Journal of …, 2024 - Springer
… Here, we review the physiological effects of secretin with distinct focus on how secretin
activates renal HCO 3 − excretion. We describe its new function as a hormone for HCO 3 − …

Coexpressed class BG protein–coupled secretin and GLP-1 receptors self-and cross-associate: impact on pancreatic islets

KG Harikumar, S Lau, PM Sexton, D Wootten… - …, 2017 - academic.oup.com
… complexes between two class B receptors, secretin receptor (SecR) and glucagonlike
peptide-1 receptor (GLP-1R), which are expressed on pancreatic islet cells. Because these …