Molecular networks in Network Medicine: Development and applications

EK Silverman, HHHW Schmidt… - … Systems Biology and …, 2020 - Wiley Online Library
… We discuss briefly the types of molecular data that are used in molecular network analyses,
… inferring molecular networks, and review efforts to validate and visualize molecular networks. …

[HTML][HTML] Inferring causal molecular networks: empirical assessment through a community-based effort

SM Hill, LM Heiser, T Cokelaer, M Unger, NK Nesser… - Nature …, 2016 - nature.com
… The networks spanned 32 biological contexts and were scored in terms of causal validity
with … a practical way to empirically assess inferred molecular networks in a causal sense. …

[HTML][HTML] Diffany: an ontology-driven framework to infer, visualise and analyse differential molecular networks

SV Landeghem, TV Parys, M Dubois, D Inzé… - BMC …, 2016 - Springer
… further explore the rewiring events in their network context. Unfortunately, there is currently
no … -specific networks on the one hand, and produce intercomparable differential networks on …

Mol2Context-vec: learning molecular representation from context awareness for drug discovery

Q Lv, G Chen, L Zhao, W Zhong… - Briefings in …, 2021 - academic.oup.com
… of molecular substructures. And the obtained molecular context representation can capture
… used as a reliable and effective tool for molecular expression. Availability: The source code …

Molecular pathways and the contextual explanation of molecular functions

G Boniolo, R Campaner - Biology & Philosophy, 2018 - Springer
… First of all, each pathway “lives” in a molecular context which is defined by a set of
molecules (in our case, Glc&HK&GPI&PFK&ATP&ATP) and which identifies the function of any …

Integrating molecular networks with genetic variant interpretation for precision medicine

E Capriotti, K Ozturk, H Carter - Wiley Interdisciplinary Reviews …, 2019 - Wiley Online Library
… Instead the severity of perturbation to the complex network of molecular interactions in the
cell may … Studying variants in the context of protein–protein interaction (PPI) networks and …

[HTML][HTML] Systematic evaluation of molecular networks for discovery of disease genes

JK Huang, DE Carlin, MK Yu, W Zhang, JF Kreisberg… - Cell systems, 2018 - cell.com
… Correcting for size, we find that the DIP network provides the … network with both high
efficiency and performance. This work provides a benchmark for selection of molecular networks in …

[HTML][HTML] Network-based strategies in metabolomics data analysis and interpretation: from molecular networking to biological interpretation

L Perez De Souza, S Alseekh, Y Brotman… - Expert Review of …, 2020 - Taylor & Francis
… Additionally, the representation of data from metabolomics within the context of metabolic
networks is intuitive and allows for the use of statistical analysis that can better summarize …

[HTML][HTML] Convolutional networks for supervised mining of molecular patterns within cellular context

I de Teresa-Trueba, SK Goetz, A Mattausch… - Nature …, 2023 - nature.com
… the molecular constituents of cells and tissues. We present DeePiCt (deep picker in context),
… cellular ribosomes, with emphasis on their contextual association with mitochondria and the …

Regulatory elements in molecular networks

AS Doane, O Elemento - Wiley Interdisciplinary Reviews …, 2017 - Wiley Online Library
Regulatory elements determine the connectivity of molecular networks and mediate a … different
types of regulatory elements found in molecular networks with a focus on DNA regulatory …