failure, shock or multiorgan dysfunction, often accompanied by systemic hyperinflammation
and dysregulated cytokine release. These features are linked to the intense and rapid
stimulation of the innate immune response. The NACHT, LRR and PYD domains-containing
protein 3 (NLRP3) inflammasome is a central player in inflammatory macrophage activation
which via caspase-1 activation leads to the release of the mature forms of the …