Pharmacogenomics of the natriuretic peptide system in heart failure
A Abuzaanona, D Lanfear - Current heart failure reports, 2017 - Springer
… Data from our lab also supports genetic variation in NPR3 impacting expression [71]. Taking
… were significantly associated with polymorphisms in MME [71]. We further demonstrated that …
… were significantly associated with polymorphisms in MME [71]. We further demonstrated that …
A functional study of blood-pressure-associated SNPs at natriuretic peptide receptor C gene locus.
M Ren - 2016 - qmro.qmul.ac.uk
… Their major alleles are related with blood pressure elevation. … mechanism for BP-associated
SNPs at NPR3 locus to influence BP … It is intuitive that nonsynonymous SNPs (amino acid …
SNPs at NPR3 locus to influence BP … It is intuitive that nonsynonymous SNPs (amino acid …
Human genotyping and an experimental model reveal NPR-C as a possible contributor to morbidity in coarctation of the aorta
JF LaDisa Jr, A Tomita-Mitchell… - Physiological …, 2019 - journals.physiology.org
… evidence of natriuretic peptide receptor C (NPR-C; aka NPR3) … In contrast, rs146301345
was significantly enriched in our … In contrast to finding new rare SNPs, we focused on SNPs …
was significantly enriched in our … In contrast to finding new rare SNPs, we focused on SNPs …
[HTML][HTML] Genomic and “Polyomic” Studies of Cardiovascular and Inflammatory Diseases: Human genotyping and an experimental model reveal NPR-C as a possible …
JF LaDisa Jr, A Tomita-Mitchell, K Stamm… - Physiological …, 2019 - ncbi.nlm.nih.gov
… evidence of natriuretic peptide receptor C (NPR-C; aka NPR3) … In contrast, rs146301345
was significantly enriched in our … In contrast to finding new rare SNPs, we focused on SNPs …
was significantly enriched in our … In contrast to finding new rare SNPs, we focused on SNPs …
[HTML][HTML] RNA-Seq data analysis reveals novel nonsense mutations in the NPR3 gene leading to the progression of intellectual disability disorder
P Garg, F Jamal, P Srivastava - Heliyon, 2024 - cell.com
… gene expression and single nucleotide polymorphism (SNPs)… This missense mutation reveals
a major role in causing ID. … X-ray structure of human natriuretic peptide receptor-C (PDB ID…
a major role in causing ID. … X-ray structure of human natriuretic peptide receptor-C (PDB ID…
NPR3 protects cardiomyocytes from apoptosis through inhibition of cytosolic BRCA1 and TNF-α
… Natriuretic peptide receptor 3 (NPR3) is a clearance receptor … NPR3 and found 7 novel
non-synonymous single-nucleotide … The first important finding of this study is the up-regulation of …
non-synonymous single-nucleotide … The first important finding of this study is the up-regulation of …
Recent advances in the genetics of hypertension
… the non-significant association between rs9791170 polymorphism and hypertension. …
SNPs were mapped to natriuretic peptide receptor 3-chromosome 5 open reading frame 23 (NPR3-…
SNPs were mapped to natriuretic peptide receptor 3-chromosome 5 open reading frame 23 (NPR3-…
Genomics of hypertension
… that disruption of gene function can have a major impact on BP, … , rare nonsynonymous
variants in salt-handling genes have … Natriuretic Peptide Receptor 3 (NPR3) is another plausible …
variants in salt-handling genes have … Natriuretic Peptide Receptor 3 (NPR3) is another plausible …
[HTML][HTML] Epigenetic and transcriptional regulation of the human angiotensinogen gene by high salt
S Perla, A Kumar - bioRxiv, 2023 - ncbi.nlm.nih.gov
… genes were found to be upregulated (Fig.4D). Npr3 encodes natriuretic peptide receptor
3. … ): nonsynonymous polymorphism results in significant reduction in protein expression …
3. … ): nonsynonymous polymorphism results in significant reduction in protein expression …
[HTML][HTML] SLC39A8 gene encoding a metal ion transporter: discovery and bench to bedside
… Two decades later, the Nebert lab [7] used polymorphic microsatellite markers and … [28],
kidney exhibited highly significant upregulation of Npr3 (natriuretic peptide receptor-3). In a Sglt2…
kidney exhibited highly significant upregulation of Npr3 (natriuretic peptide receptor-3). In a Sglt2…