… Several genetic susceptibility loci associated with diabetic nephropathy have been
documented, but no causative variants implying novel pathogenetic mechanisms have been …

… eventually leading to kidney disease. Red arrows … loci associated with specific forms of renal
disease (Table 1). SNPs within MT-HV2, MT-CO1, and MT-CO2c have been associated with …

… may point to a genomic region containing a susceptibility locus. Linkage analysis has been
most successful for rare single-gene disorders, in which rare variants have major effects on …

… to harbor common susceptibility alleles associated with CAD … how these loci associate with
CAD in T1D patients. Results of this … kidney disease [32], highlighting its importance in kidney …

… We additionally found that the UMOD locus known to be associated with kidney function in
the general population was also associated with advanced CKD (stage G3b). Experimental …

… studies have linked its polymorphisms to the development of diabetic microvascular
complications, such as DN [63]. ACE I/D is the most susceptible locus for DN. In the Diabetes Control …

… correlation between diabetic kidney disease and failure at … −6 ) in pathogenesis of diabetic
kidney disease. These data provide … diabetic kidney disease in those with type 1 diabetes and …

… T1DM is also associated with an increased risk of comorbidities, such as … disease,
retinopathy, and diabetic kidney disease (DKD), further contributing to the burden of this disease. …

… of non-diabetic kidney disease. The aim of this study was to identify novel genetic susceptibility
loci for DN using a customized DNA chip in Korean diabetic patients. We conducted a two…

… is an early sign of diabetic kidney disease, affecting every … susceptibility loci for DN with
genome-wide statistical significance, ie p-value < 5 × 10 −8 , with the main findings often related …