Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer

J Barontini, M Antinucci, S Tofanelli, M Cammalleri… - BMC …, 2017 - Springer
… receptors that selectively binds to salicin, a natural antipyretic … a possible link between
TAS2R16 allelic variants and CRC risk. To … However, this difference maybe just due to statistical …

A bio-cultural approach to the study of food choice: The contribution of taste genetics, population and culture

DS Risso, C Giuliani, M Antinucci, G Morini… - Appetite, 2017 - Elsevier
… (TAS2R16) strongly differentiated populations and was associated to salicin bitterness … that
the rs860170 derived allele could increase the tolerance level for salicin bitterness and other …

Generalised Periodontitis: Examining TAS2R16 Serum Levels and Common Gene Polymorphisms (rs860170, rs978739, rs1357949)

A Kriauciunas, G Gedvilaite, A Bruzaite, G Zekonis… - Biomedicines, 2024 - mdpi.com
… a statistically significant difference in TAS2R16 rs860170 (TT, … of all selected TAS2R16 SNP
genotypes and alleles are … Activation of TAS2R16 signaling by salicin inhibited the release …

Genes from the TAS1R and TAS2R Families of Taste Receptors: Looking for Signatures of Their Adaptive Role in Human Evolution

C Valente, L Alvarez, PI Marques… - Genome biology and …, 2018 - academic.oup.com
… patterns of variation displayed by TAS2R16 and TAS2R38 … of selection, we calculated several
statistics based on the allele … which originated ∼82 ± 10 ka through the G1114A mutation. …

[HTML][HTML] Global population genetics and diversity in the TAS2R bitter taste receptor family

SP Wooding, VA Ramirez - Frontiers in Genetics, 2022 - frontiersin.org
… of allele frequencies, the distribution of allele frequencies at … that populations are differentiated
with respect to variation in … in TAS2R16, receptor response, and the perception of salicin, …

The bitter taste receptor TAS2R16 achieves high specificity and accommodates diverse glycoside ligands by using a two-faced binding pocket

A Thomas, C Sulli, E Davidson, E Berdougo… - Scientific reports, 2017 - nature.com
Origin and differential selection of allelic variation at TAS2R16 associated with salicin
bitter taste sensitivity in Africa. Molecular biology and evolution 31, 288–302, doi:10.1093/molbev/…

Copy Number Variation in TAS2R Bitter Taste Receptor Genes: Structure, Origin, and Population Genetics

N Roudnitzky, D Risso, D Drayna, M Behrens… - Chemical …, 2016 - academic.oup.com
associated with receptor function and phenotypic variability. … determine levels of differentiation
across worldwide populations… allele frequencies provide an indication of population origins

Lineage‐specific duplication and adaptive evolution of bitter taste receptor genes in bats

H Jiao, Y Wang, L Zhang, P Jiang, H Zhao - Molecular ecology, 2018 - Wiley Online Library
… of Tas2r16 in Myotis davidii showed differential sensitivities … -derived errors and allelic
variations, aiming to avoid inclusion … five bat Tas2r16 receptors recognized arbutin and D-salicin (…

[图书][B] Exploring Worldwide Diversity and Variation in Human Gustatory Genes

VA Ramirez - 2023 - search.proquest.com
… diversity, differentiation, and signatures of natural selection within … of an allele on TAS2R16,
which confers sensitivity to salicin, … has high levels of allelic variation and that among global …

Lowered sensitivity of bitter taste receptors to β-glucosides in bamboo lemurs: an instance of parallel and adaptive functional decline in TAS2R16?

A Itoigawa, F Fierro, ME Chaney… - … of the Royal …, 2021 - royalsocietypublishing.org
history of TAS2R16 functions, we inferred TAS2R16TAS2R16 showed lower responses
to linamarin and salicin … To clarify whether this difference in sensitivity influences food choice …