Oropharyngeal administration of silica in Swiss mice: A robust and reproducible model of occupational pulmonary fibrosis
Pulmonary fibrosis (PF) is a lethal end stage of interstitial lung disease with increasing
prevalence. The disease burden of PF has seen a sharp surge in the past two decades
owing to entry of heavy amount of particulate matter due to industrialization and
urbanization. In this work, we developed an oropharyngeal aspiration model of silica (1.5
mg/mice) induced pulmonary fibrosis as a homogeneous, reproducible, simple and
alternative strategy in Swiss albino mice. Various BALF (protein, albumin, cell count) …
prevalence. The disease burden of PF has seen a sharp surge in the past two decades
owing to entry of heavy amount of particulate matter due to industrialization and
urbanization. In this work, we developed an oropharyngeal aspiration model of silica (1.5
mg/mice) induced pulmonary fibrosis as a homogeneous, reproducible, simple and
alternative strategy in Swiss albino mice. Various BALF (protein, albumin, cell count) …
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