Adipocyte differentiation

JM Moreno-Navarrete, JM Fernández-Real - Adipose tissue biology, 2017 - Springer
… types in some other positions, such as loose connective tissue. There are two kinds of adipose
tissue, white adipose tissue (WAT) and brown adipose tissue (BAT), both of which differ in …

PPARs-orchestrated metabolic homeostasis in the adipose tissue

C Sun, S Mao, S Chen, W Zhang, C Liu - International journal of …, 2021 - mdpi.com
… mice, adipose tissue-specific loss of PPARγ led to critical atrophy of adipose tissue and
was … mutants in human subjects also supports the important role of PPARγ in adipose tissue

PPARs and metabolic disorders associated with challenged adipose tissue plasticity

P Corrales, A Vidal-Puig, G Medina-Gómez - International Journal of …, 2018 - mdpi.com
… , PPARγ declines, thus accelerating adipose tissue insulin resistance and facilitating lipolysis
in the subcutaneous adipose tissue … also decreases in adipose tissue from obese pregnant …

Differentiation of human adipose stromal cells in vitro into insulin-sensitive adipocytes

O Huttala, R Mysore, JR Sarkanen, T Heinonen… - Cell and tissue …, 2016 - Springer
… are needed. The aims of this study are (1) to improve the existing natural adipose tissue
accumulation per cell and adipocyte-specific gene expression (PPARγ, adiponectin, AP2, leptin, …

Molecular mechanisms of PPAR-γ governing MSC osteogenic and adipogenic differentiation

H Zhuang, X Zhang, C Zhu, X Tang… - Current stem cell …, 2016 - ingentaconnect.com
… PPAR- 2 has been found to have specific expression in adipose tissue, with an essential
role in adipocyte differentiation, phenotype and function [37]. All forms have considerable …

Peroxisome proliferator-activated receptor-γ: master regulator of adipogenesis and obesity

X Shao, M Wang, X Wei, S Deng, N Fu… - Current stem cell …, 2016 - ingentaconnect.com
… regulator of stem cell differentiation. The expression of PPAR- is ubiquitous in adipose tissue
and immune sys… A lot of PPARγ transgenic animal models such as mice heterozygous for …

PPAR-γ and Wnt regulate the differentiation of MSCs into adipocytes and osteoblasts respectively

Y Li, D Jin, W Xie, L Wen, W Chen, J Xu… - Current stem cell …, 2018 - ingentaconnect.com
… natal human tissues, including adipose tissue, dental pulp, cervical tissue, and muscle tissue,
and … and adipogenesis, and suggests that PPARγ is at the center of the regulatory system. …

De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity

M Shao, L Vishvanath, NC Busbuso, C Hepler… - Nature …, 2018 - nature.com
Pparγ is both necessary and sufficient for adipocyte differentiation 40,41,42,43 . Pparg … of
the local adipose tissue microenvironment in regulating adipocyte progenitor activity. Thus, our …

In vitro and ex vivo models of adipocytes

J Dufau, JX Shen, M Couchet… - … of Physiology-Cell …, 2021 - journals.physiology.org
… It may take place during adulthood, allowing adipocyte turnover and adipose tissue
Whereas the requirement of PPARγ agonists is mandatory for optimal differentiation of human …

[HTML][HTML] PPARγ and PPARα synergize to induce robust browning of white fat in vivo

T Kroon, M Harms, S Maurer, L Bonnet… - Molecular …, 2020 - Elsevier
… and subsequent synergistic effect with PPARγ activation in adipose tissues. Indeed, tesaglitazar
… correlated with Ucp1 levels in adipose tissues in all in vivo studies performed with dual …