Adiponectin promotes preadipocyte differentiation via the PPARγ pathway

W Yang, C Yang, J Luo, Y Wei… - Molecular …, 2018 - spandidos-publications.com
… and peroxisome proliferator‑activated receptor γ (PPARγ). The present … adipose tissue by
stimulating mature adipocytes with lipopolysaccharide (LPS); subsequently, the differentiation

PPARγΔ5, a naturally occurring dominant-negative splice isoform, impairs PPARγ function and adipocyte differentiation

M Aprile, S Cataldi, MR Ambrosio, V D'Esposito, K Lim… - Cell reports, 2018 - cell.com
… of PPARγ, which lacks the entire ligand-binding domain. PPARγΔ5 is endogenously expressed
in human adipose tissue and, during adipocyte differentiation, … reducing PPARγ activity. …

[HTML][HTML] Human adipose tissue microvascular endothelial cells secrete PPARγ ligands and regulate adipose tissue lipid uptake

S Gogg, A Nerstedt, J Boren, U Smith - Jci Insight, 2019 - ncbi.nlm.nih.gov
… Human adipose cells cannot secrete endogenous PPARγ ligands and are dependent …
adipose tissue microvascular endothelial cells (aMVECs) cross-talk with the adipose cells for fatty

The elusive endogenous adipogenic PPARγ agonists: Lining up the suspects

P Hallenborg, RK Petersen, I Kouskoumvekaki… - Progress in Lipid …, 2016 - Elsevier
… Mice heterozygous for PPARγ have less adipose tissue when fed a high-fat diet although
this could be correlated to increased energy expenditure [25], [28]. In contrast to what was …

Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: An in vitro and in vivo study of adipose tissue browning

C Pellegrini, M Columbaro, E Schena… - … & molecular medicine, 2019 - nature.com
… Although we cannot provide here an explanation for this effect, we suggest that differentially
expressed PPARγ regulators 54 as well as differentially expressed nuclear envelope …

Peroxisome proliferator-activated receptor (PPAR) in regenerative medicine: molecular mechanism for PPAR in stem cells' adipocyte differentiation

Q Xie, T Tian, Z Chen, S Deng, K Sun… - Current Stem Cell …, 2016 - ingentaconnect.com
Adipose tissue is so complex and essential that it exhibits … The adipose tissue contains not
only the adipocytes but also connective tissue matrix, stromal vascular cells, nerve tissue and …

Adipogenesis: a complex interplay of multiple molecular determinants and pathways

MA Ambele, P Dhanraj, R Giles, MS Pepper - International journal of …, 2020 - mdpi.com
Adipose tissue is essential for the regulation of energy supply and acts as a caloric reservoir
… of functional PPARγ is an absolute requirement for adipogenesis both in vitro and in vivo […

miR-301b~ miR-130b—PPARγ axis underlies the adipogenic capacity of mesenchymal stem cells with different tissue origins

L Liu, H Liu, M Chen, S Ren, P Cheng, H Zhang - Scientific reports, 2017 - nature.com
… Furthermore, UC-MSC and Ad-MSC presented stronger proliferative ability than BM-MSC
according to our experience, which may make umbilical cord and adipose tissue ideal …

Long noncoding RNA Plnc1 controls adipocyte differentiation by regulating peroxisome proliferator‐activated receptor γ

E Zhu, J Zhang, Y Li, H Yuan, J Zhou… - The FASEB …, 2019 - Wiley Online Library
… Plnc1 is abundantly expressed in adipose tissue, and obese mice have higher Plnc1
expression in adipose tissue than nonobese mice. Plnc1 was induced in established adipogenic …

Canagliflozin ameliorates obesity by improving mitochondrial function and fatty acid oxidation via PPARα in vivo and in vitro

D Wei, L Liao, H Wang, W Zhang, T Wang, Z Xu - Life sciences, 2020 - Elsevier
… inhibitors directly affect adipose tissues and the underlying mechanisms in vivo and in vitro.
… it failed to increase the expression of PPARδ and PPARγ even in the presence of 10 μM …