Isoimperatorin enhances 3T3‑L1 preadipocyte differentiation by regulating PPARγ and C/EBPα through the Akt signaling pathway

T Jiang, X Shi, Z Yan, X Wang… - Experimental and …, 2019 - spandidos-publications.com
Adipose tissue is the largest organ used in humans for lipid storage and mobilization based
on energy requirements: It contains several types of cells, including mature adipocytes. As …

Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues

V Pellegrinelli, S Carobbio, A Vidal-Puig - Diabetologia, 2016 - Springer
… Considering that beige adipocytes can arise from white APs by in vitro chronic exposure to
peroxisome proliferator-activated receptor γ (PPARγ) agonists, it is likely that they may share …

The Fto Gene Regulates the Proliferation and Differentiation of Pre-Adipocytes in Vitro

Y Jiao, J Zhang, L Lu, J Xu, L Qin - Nutrients, 2016 - mdpi.com
… It has been well accepted that adipose tissues play an … regulation of differentiation and
proliferation of pre-adipocytes are thought … activator PPARγ, while Fto deficiency impaired PPARγ

A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion

Y Jiang, DC Berry, A Jo, W Tang, RW Arpke… - Nature …, 2017 - nature.com
… APCs direct adipose tissue niche expansion via a PPARγ-… before and during adipose tissue
vascular niche assembly and … of PPARγ in adipose niche biology, we turned to PPARγ loss-…

Cascade regulation of PPARγ2 and C/EBPα signaling pathways by celastrol impairs adipocyte differentiation and stimulates lipolysis in 3T3-L1 adipocytes

SK Choi, S Park, S Jang, HH Cho, S Lee, S You… - Metabolism, 2016 - Elsevier
Adipose tissue mass is determined by processes regulating … We next measured mRNA
level of adipocyte differentiation markers such as PPARγ 2 , C/EBPα, aP2, and perilipin, showing …

Induction of adipose tissue browning as a strategy to combat obesity

A Kuryłowicz, M Puzianowska-Kuźnicka - International journal of …, 2020 - mdpi.com
adipocytes exist; the classical or constitutive BAT that arises during embryogenesis, and the
beige adipose tissue … of PPARγ binding activity may determine differentiation towards brown …

Studying Brown Adipose Tissue in a Human in vitro Context

I Samuelson, A Vidal-Puig - Frontiers in endocrinology, 2020 - frontiersin.org
… types including adipocytes, and can be isolated from several tissues such as … adipose-derived
stem (hMADS) cells) could be differentiated to BA-like cells when stimulated with a PPARγ

The Role of Peroxisome Proliferator-Activated Receptor Gamma (PPARG) in Adipogenesis: Applying Knowledge from the Fish Aquaculture Industry to Biomedical …

R Wafer, P Tandon, JEN Minchin - Frontiers in endocrinology, 2017 - frontiersin.org
… biology that will inform our understanding of the role of adipose tissue in obesity and related
… in white adipose tissue (WAT); however, adipogenesis in brown adipose has also recently …

Peroxisome proliferator activated receptor gamma controls mature brown adipocyte inducibility through glycerol kinase

D Lasar, M Rosenwald, E Kiehlmann, M Balaz, B Tall… - Cell reports, 2018 - cell.com
… as the master regulators of adipose tissue formation. However, their role in regulating brown
… In contrast, we could show that ablation of PPARγ in vitro and in vivo led to a reduced …

… determines the differentiation potentials of mesenchymal stem cells: a comparative study of human mesenchymal stem cells from bone marrow and adipose tissue

L Xu, Y Liu, Y Sun, B Wang, Y Xiong, W Lin… - Stem cell research & …, 2017 - Springer
… Runx2 and PPARγ are the main master transcriptional factors controlling … loci in PPARγ
promoter, respectively. We found that Runx2 promoter was hypermethylated whereas PPARγ