… of EZH2 on GATA4 transcriptional activity, we overexpressed … PRC2 interacts with GATA4
and regulates lysine methylation… transcriptional repression of FAS by PRC2, partly through the …

… Jarid2 and STAT3, to regulate their transcriptional activities ( … of PRC2 as well as its
methyltransferase activity but requires … We found that class I and II (EZH2-repressed but EPZ-…

… at some repressed genes in erythroid and megakaryocytic cells, which suggests that PRC2
is involved in … Endothelial genes normally repressed by GATA4 are upregulated in mutated …

… This supports a model in which the specific accessory proteins within PRC2.1 and PRC2.2
cooperate to direct H3K27me3 via both synergistic and independent mechanisms. …

… We also show that the GATA2 and PRC2 complexes are … GATA4, GATA5 and GATA6 are
required for the development … abrogates PRC2-mediated transcriptional GATA6 repression, …

… PRC2)-dependent manner. Loss of PRC2 does not activate poised enhancers or induce
their putative target genes in undifferentiated ESCs; however, loss of PRC2 in differentiating …

… for lysine methylation and serve as the catalytic subunit of PRC2. … PRC2 core complex,
which reciprocally enhances the binding of PCLs to CGI DNAs in pairs for gene repression…

… levels of histone 3 lysine 4 methylation (H3K4me) and histone … that Runx2 transcriptional
activity is activated by GATA4 both … In contrast, repressed genes are marked by histone 3 lysine …

… in Gata4 Prx-cKO mice. We suggest that WNT signalosome activity in MSCs requires Gata4
and … We have also shown that GATA4 represses RANKL gene expression in osteoblasts. …

… by DNA methylation and transcriptional activity. Accordingly, inhibition of transcription induced
global recruitment of PRC2 to … A PRC2 methylates and represses GATA4 activity, whereas …