Passive drug permeation through membranes and cellular distribution
… associated passive mechanisms of cellular drug permeation. … provided and used to illustrate
concepts relevant to steady-state … permeability at equilibrium the total flux J and ionized flux …
concepts relevant to steady-state … permeability at equilibrium the total flux J and ionized flux …
The critical role of passive permeability in designing successful drugs
… the free concentration gradient (the driving force for flux across the BBB) is lower and the …
This has led to the development of the extended clearance concept and intrinsic clearance …
This has led to the development of the extended clearance concept and intrinsic clearance …
[HTML][HTML] Towards a better mechanistic comprehension of drug permeation and absorption: Introducing the diffusion-partitioning interplay
MM Tzanova, E Randelov, PC Stein, M Hiorth… - International Journal of …, 2021 - Elsevier
… In order to obtain the apparent permeability coefficient (P app , cm/s) fluxes were … the effect
of media viscosity on the passive diffusion and permeability of model drugs CAF and HC, the …
of media viscosity on the passive diffusion and permeability of model drugs CAF and HC, the …
Understanding of relationship between phospholipid membrane permeability and self-diffusion coefficients of some drugs and biologically active compounds in model …
SV Blokhina, TV Volkova, VA Golubev… - Molecular …, 2017 - ACS Publications
… permeability mechanism for drug discovery is passive … flux rates were used to calculate
the apparent permeability … A model conception considering the passive diffusion through the …
the apparent permeability … A model conception considering the passive diffusion through the …
Diffusion and Flux Improvement of Drugs through Complexation
… (ii) The idea of facilitated passive diffusion originated from the phenomenon of unusual … We
have used the words diffusion/flux and diffusion/permeation as the case may in this review to …
have used the words diffusion/flux and diffusion/permeation as the case may in this review to …
Intestinal permeability and drug absorption: predictive experimental, computational and in vivo approaches
D Dahlgren, H Lennernäs - Pharmaceutics, 2019 - mdpi.com
… minimal effects on membrane permeability and water flux [35]. … concept of the pH partitioning
theory for predicting passive … of passive permeation according to their ability to spread the …
theory for predicting passive … of passive permeation according to their ability to spread the …
Mechanisms and extent of enhanced passive permeation by colloidal drug particles
… to membrane permeability using Fick’s law of diffusion. (29) … diffusion coefficients that
were calculated from experimental flux data to compensate for enhanced passive permeation …
were calculated from experimental flux data to compensate for enhanced passive permeation …
Theory and applications of diffusion and dissolution
X Li, B Jasti - Theory and Practice of Contemporary …, 2021 - taylorfrancis.com
… or compare the permeation of a drug through various … etc., takes place mainly by passive
diffusion. If one observes the fate of … As defined in Equation 7.2, flux is the rate of permeation per …
diffusion. If one observes the fate of … As defined in Equation 7.2, flux is the rate of permeation per …
Particle Size, Dose, and Confinement Affect Passive Diffusion Flux through the Membrane Concentration Boundary Layer
… One limiting case of importance is the maximum flux. When the surface concentration at
the … to diffusion would be the membrane permeability. The true maximum membrane flux is …
the … to diffusion would be the membrane permeability. The true maximum membrane flux is …