[HTML][HTML] Identification of reliable biomarkers of human papillomavirus 16 methylation in cervical lesions based on integration status using high-resolution melting …
L Liu, C Ying, Z Zhao, L Sui, X Zhang, C Qian… - Clinical …, 2018 - Springer
… However, there were no obvious preferential sites in the human genome among the three
groups. Furthermore, disruption of HPV 16 was scattered throughout all genes from LCR to L1, …
groups. Furthermore, disruption of HPV 16 was scattered throughout all genes from LCR to L1, …
[HTML][HTML] HPV16 integration probably contributes to cervical oncogenesis through interrupting tumor suppressor genes and inducing chromosome instability
JW Zhao, F Fang, Y Guo, TL Zhu, YY Yu… - Journal of Experimental …, 2016 - Springer
… integration of human papilloma virus (HPV) into host genome is one of the critical steps that
lead to the progression of precancerous lesion … a clear preference at genomic fragile sites [41…
lead to the progression of precancerous lesion … a clear preference at genomic fragile sites [41…
[HTML][HTML] Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology
Y Liu, Z Lu, R Xu, Y Ke - Oncotarget, 2016 - ncbi.nlm.nih.gov
… integration and progression of cervical dysplastic lesions to … In addition to HPV 16, we also
detected HPV18 (n = 4), 58 (n … E2 gene is frequently disrupted upon HPV integration, and the …
detected HPV18 (n = 4), 58 (n … E2 gene is frequently disrupted upon HPV integration, and the …
Dysregulation of host cellular genes targeted by human papillomavirus (HPV) integration contributes to HPV‐related cervical carcinogenesis
R Zhang, C Shen, L Zhao, J Wang… - … Journal of Cancer, 2016 - Wiley Online Library
… of 499 loci showed preferred HPV integration into intragenic … lesions to cervical cancer, the
frequency of viral genome … of integration-targeted genes (ITGs), which were disrupted directly …
frequency of viral genome … of integration-targeted genes (ITGs), which were disrupted directly …
Human papillomavirus (HPV) integration signature in cervical lesions: identification of MACROD2 gene as HPV hot spot integration site
J Zhao, W Zheng, L Wang, H Jiang, X Wang… - Archives of Gynecology …, 2023 - Springer
… HPV integration, the disruption of the E1 or E2 gene (a negative regulator of oncogenes E6
and E7) is preferred… the mechanisms that might promote integration and carcinogenesis [16]. …
and E7) is preferred… the mechanisms that might promote integration and carcinogenesis [16]. …
[HTML][HTML] Recurrent integration of human papillomavirus genomes at transcriptional regulatory hubs
A Warburton, TE Markowitz, JP Katz, JM Pipas… - NPJ Genomic …, 2021 - nature.com
… in W12 cervical keratinocytes (Supplementary Data Table 16)… at an HPV integration site
in cervical lesion derived cells 27 . … integration at these regions could result in disruption of …
in cervical lesion derived cells 27 . … integration at these regions could result in disruption of …
Recent Topics of Human Papillomavirus and Cervical Cancer
I Kukimoto - … , Diagnosis, and Clinical Management of Cervical …, 2024 - Springer
… APOBEC3-mediated cytosine deamination preferentially … HPV genome replication and
integration in cervical lesions. … are frequently disrupted or amplified with HPV integration include …
integration in cervical lesions. … are frequently disrupted or amplified with HPV integration include …
[HTML][HTML] The Immune Microenvironment in Human Papilloma Virus-Induced Cervical Lesions—Evidence for Estrogen as an Immunomodulator
J Rs - Frontiers in Cellular and Infection Microbiology, 2021 - frontiersin.org
… in the intestine and extraintestinal mucosal sites. Elevated tissue … E2 ORFs are disrupted
during genomic integration. Both these … HPV 16 E6 oncoprotein induces the expression of PGE2 …
during genomic integration. Both these … HPV 16 E6 oncoprotein induces the expression of PGE2 …
HPV oncogenes expressed from only one of multiple integrated HPV DNA copies drive clonal cell expansion in cervical cancer
L Yu, V Majerciak, A Lobanov, S Mirza, V Band, H Liu… - Mbio, 2024 - Am Soc Microbiol
… HPV DNA integration and progression of cervical lesions. We … Intron 1 of CCAT1 was disrupted
by HPV18 DNA integration, … preferential integration in fragile regions for HPV integration, …
by HPV18 DNA integration, … preferential integration in fragile regions for HPV integration, …
Human papillomavirus oncoproteins and post-translational modifications: generating multifunctional hubs for overriding cellular homeostasis
O Basukala, V Sarabia-Vega, L Banks - Biological chemistry, 2020 - degruyter.com
… HPV-18 E6 which preferentially associates with discs large homolog 1 (DLG1), while HPV-…
increased during cervical lesion progression and this positively correlated with HPV-16 E6 …
increased during cervical lesion progression and this positively correlated with HPV-16 E6 …