Measuring biological aging in humans: A quest

L Ferrucci, M Gonzalez‐Freire, E Fabbri… - Aging cell, 2020 - Wiley Online Library
… drivers of biological aging. However, reliable and valid assays for their quantification
should be developed before they can be used in human research and in clinical applications. …

A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge

D Kwon, DW Belsky - Geroscience, 2021 - Springer
… Methods to quantify biological aging are emerging as new measurement tools for …
Publicly available software packages to compute biological aging measurements from DNA …

Eleven telomere, epigenetic clock, and biomarker-composite quantifications of biological aging: do they measure the same thing?

DW Belsky, TE Moffitt, AA Cohen… - American journal of …, 2018 - academic.oup.com
… The implication of this analysis is that several methods proposed to quantify biological
aging in fact appear to quantify different “things.” Although each of these measures has its own …

Association of blood chemistry quantifications of biological aging with disability and mortality in older adults

DC Parker, BN Bartlett, HJ Cohen… - The Journals of …, 2020 - academic.oup.com
adults in the United States (N = 1,374, age range = 71–102, 35% male, 52% African American).
We quantified biological aging … methods to quantify biological aging in older adults, but …

Quantification of the biological age of the brain using neuroimaging

JH Cole, K Franke, N Cherbuin - Biomarkers of human aging, 2019 - Springer
… The volume containing this this chapter is testament to the breadth of research into
biological ageing across many different systems, organs, tissues and cells. Better integration of …

Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm

DW Belsky, A Caspi, L Arseneault, A Baccarelli… - Elife, 2020 - elifesciences.org
… a fourth, longitudinal, study of young people to test if DunedinPoAm was accelerated by …
slowed the rate of biological aging as measured by a blood-chemistry biological-age composite …

Quantification of biological age as a determinant of age-related diseases in the Rotterdam Study: a structural equation modeling approach

R Waziry, L Gras, S Sedaghat, H Tiemeier… - European journal of …, 2019 - Springer
… Unlike studying single diseases, quantifying biological aging requires methods that take …
pace of aging and outcomes as cognitive decline in a homogenous sample of young adults [11]. …

Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy

ML Elliott, A Caspi, RM Houts, A Ambler, JM Broadbent… - Nature aging, 2021 - nature.com
… , dental and pulmonary systems, and quantified age-related decline shared … biological
aging in the Dunedin Study the ‘Pace of Aging’. In a 2015 article, we quantified the Pace of Aging

[HTML][HTML] Quantitative characterization of biological age and frailty based on locomotor activity records

TV Pyrkov, E Getmantsev, B Zhurov… - Aging (Albany …, 2018 - ncbi.nlm.nih.gov
… score is a quantitative measure of the biological aging progress. These data suggest that the
… for quantifying biological age in this study and in almost every other kind of biological signal …

Measuring biological age using omics data

J Rutledge, H Oh, T Wyss-Coray - Nature Reviews Genetics, 2022 - nature.com
… to quantify a composite rate of biological ageing 74 . The DunedinPoAm DNAm clock was
then trained with standard methods to estimate this rate with CpG methylation. This clock had …