Isolated recessive nail dysplasia caused by FZD6 mutations: report of three families and review of the literature

C Kasparis, D Reid, NJ Wilson, V Okur… - Clinical and …, 2016 - academic.oup.com
… in 20nail dystrophy in the absence of other cutaneous or extracutaneous findings. A few case
reports have identified mutations in the Frizzled 6 (FZD6) gene … , all 20 nails were similarly …

A possible founder mutation in FZD6 gene in a Turkish family with autosomal recessive nail dysplasia

C Saygı, Y Alanay, U Sezerman, A Yenenler… - BMC medical …, 2019 - Springer
… 1676_1683delGAACCAGC, in FZD6 gene which causes a … of this frameshift mutation may
be caused by the change in … It belongs to the frizzled family and, in general, frizzled family …

A novel pathogenic variant in the FZD6 gene causes recessive nail dysplasia in a large Iranian kindred

J Mohammadi-Asl, MR Pourreza, A Mohammadi… - Journal of …, 2017 - Elsevier
… which is non-coding. It encodes a 706 amino acid protein containing seven transmembrane
domains and seven topological domains. It is a member of the Frizzled gene family, whose …

A novel pathogenic variant in the FZD6 gene causes recessive nail dysplasia in a Moroccan family

PL Lanvin, L Lebreton, E Lasseaux… - Clinical and …, 2023 - academic.oup.com
… and hard nails with very slow growth of toenails and fingernails. At least five genes are known
… The FZD gene family encodes frizzled (FZD) receptors, which act as receptors for the Wnt …

[HTML][HTML] First report of a known pathogenic variant in the FZD6 gene, in an Iranian family with recessive nail dysplasia: A case report

MMAG Cheshmeh, A Najizadeh… - Iranian Journal of …, 2019 - ncbi.nlm.nih.gov
… as a condition resulting in nail dystrophy in the absence of … the nail disorder with a mutation
in the gene frizzled causing … The growing of toenails was very slower than fingernails. At …

Congenital Nail Disorders among Children with Suspected Ectodermal Dysplasias

S Maier-Wohlfart, C Aicher, I Willershausen, N Peschel… - Genes, 2022 - mdpi.com
… SSPS displayed characteristic nail dystrophies (six males and … disorders, among which FZD6
(frizzled class receptor 6) and … disorders have not yet been identified, the increasing usage …

[PDF][PDF] Congenital Nail Disorders among Children with Suspected Ectodermal Dysplasias. Genes 2022, 13, 2119

S Maier-Wohlfart, C Aicher, I Willershausen, N Peschel… - 2022 - edinetwork.org
… SSPS displayed characteristic nail dystrophies (six males and … disorders, among which FZD6
(frizzled class receptor 6) and … disorders have not yet been identified, the increasing usage …

Molecular pathway-based classification of ectodermal dysplasias: first five-yearly update

N Peschel, JT Wright, MI Koster, AJ Clarke, G Tadini… - Genes, 2022 - mdpi.com
… , an X-chromosomal gene encoding the signaling protein … receptor of the Frizzled receptor
family transmits the biological … We are continuing this research that may allow an expansion of …

WNT signaling and bone: lessons from skeletal dysplasias and disorders

Y Huybrechts, G Mortier, E Boudin… - Frontiers in …, 2020 - frontiersin.org
… In addition to increasing the insights in the pathways regulating … LDL)-related receptor (LRP)5/6
and Frizzled (FZD). This activation … dysplasias caused by mutations in genes that encode

Monoallelic and biallelic variants in LEF1 are associated with a new syndrome combining ectodermal dysplasia and limb malformations caused by altered WNT …

W Dufour, S Alawbathani, AS Jourdain, M Asif… - Genetics in …, 2022 - Elsevier
… The interaction between the WNT ligand and the Frizzled … After incubation with
increasing concentrations of the … cause autosomal recessive ectodermal dysplasia 9, hair/nail