Ageing is a degenerative process leading to tissue dysfunction and death. A proposed
cause of ageing is the accumulation of epigenetic noise, which disrupts youthful gene
expression patterns that are required for cells to function optimally and recover from damage–
. Changes to DNA methylation patterns over time form the basis of an 'ageing clock',, but
whether old individuals retain information to reset the clock and, if so, whether this would
improve tissue function is not known. Of all the tissues in the body, the central nervous …