Methylglyoxal, a potent inducer of AGEs, connects between diabetes and cancer

J Bellier, MJ Nokin, E Lardé, P Karoyan… - Diabetes research and …, 2019 - Elsevier
… favor cancer cell proliferation, migration and resistance to … , AGEs can generate substantial
cellular damage. All proteins … major alterations of fundamental cellular processes such as …

mpsmpRole of methylglyoxal and redox homeostasis in microbe-mediated stress mitigation in plants

S Garai, B Bhowal, M Gupta, S Sopory… - Plant Science, 2023 - Elsevier
important mechanisms of stress alleviation. Further, we also examine the microbial mechanisms
of resistance … protect the organism from ROS-mediated extensive oxidative damage (Fig. …

Methylglyoxal induces p53 activation and inhibits mTORC1 in human umbilical vein endothelial cells

X Zhang, A Rodriguez-Niño, DO Pastene, P Pallavi… - Scientific Reports, 2021 - nature.com
… changes include vascular damage, insulin resistance and low … to DNA damage and cellular
stress and plays a critical role in … In keeping with carnosine’s ability to scavenge reactive …

[HTML][HTML] Alu antisense RNA ameliorates methylglyoxal-induced human lens epithelial cell apoptosis by enhancing antioxidant defense

PY Wu, N Ji, CG Wu, XD Wang, X Liu… - International Journal …, 2023 - ncbi.nlm.nih.gov
… Although the transfection efficiency of Lipofectamine 2000 was relatively high, this … damage
and increased proliferation in HLECs. It has been reported that SINE RNAs have important

Advanced glycation endproducts in diabetes-related macrovascular complications: focus on methylglyoxal

CG Schalkwijk, LR Micali, K Wouters - Trends in Endocrinology & …, 2023 - cell.com
… glucose levels because of insufficient production of insulin or due to insulin resistance [ …
Endothelial injury is an important first step in allowing cholesterol infiltration into the vessel wall. …

Effect of methylglyoxal on reactive oxygen species, KI-67, and caspase-3 expression in MCF-7 cells

D Paramita, JDP Wisnubroto - Experimental and Molecular Pathology, 2018 - Elsevier
damage, or accumulation of a specific MG-derived advanced glycation end product (AGE). …
and activation of ASK1 are important for initiating methylglyoxal-induced apoptosis process …

Glyoxal in foods: Formation, metabolism, health hazards, and its control strategies

M Zhang, C Huang, J Ou, F Liu, S Ou… - Journal of Agricultural …, 2024 - ACS Publications
… by scholars focuses mainly on methylglyoxal and acrolein. This … pathway targets and
ROS-mediated biomolecules by blocking … inhibitors that are more resistant to digestion should also …

[HTML][HTML] Antioxidant and pro-oxidant actions of resveratrol on human serum albumin in the presence of toxic diabetes metabolites: Glyoxal and methyl-glyoxal

NMO Arcanjo, C Luna, MS Madruga… - Biochimica et Biophysica …, 2018 - Elsevier
… Understanding the molecular basis of disease is crucial to … These condensations may
contribute to increasing resistance to … Red arrows denote ROS-mediated pathways. Blue arrows …

Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and …

H Li, Z Tang, P Chu, Y Song, Y Yang, B Sun… - Free Radical Biology …, 2018 - Elsevier
Methylglyoxal (MGO) is the most potent precursor of advanced … In summary, Akt-mediated
Nrf2/HO-1 signal is important in … The oligomycin-resistant respiration rate is most commonly …

The effects of methylglyoxal on the mitochondria

MP Kalapos, L de Bari - Mitochondrial Intoxication, 2023 - Elsevier
… of its bioenergetic function is essential in survival. This role is … their efficiency competes with
that of glyoxalase route. … Bax protein expression, activation of ROS-mediated MAPKs (p-JNK, …