Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
MJ Gandal, JR Haney, NN Parikshak, V Leppa… - Science, 2018 - science.org
The predisposition to neuropsychiatric disease involves a complex, polygenic, and
pleiotropic genetic architecture. However, little is known about how genetic variants impart
brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of
molecular brain-based phenotypes across five major psychiatric disorders—autism,
schizophrenia, bipolar disorder, depression, and alcoholism—compared with matched
controls. We identified patterns of shared and distinct gene-expression perturbations across …
pleiotropic genetic architecture. However, little is known about how genetic variants impart
brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of
molecular brain-based phenotypes across five major psychiatric disorders—autism,
schizophrenia, bipolar disorder, depression, and alcoholism—compared with matched
controls. We identified patterns of shared and distinct gene-expression perturbations across …
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
MJ Gandal, JR Haney, NN Parikshak… - FOCUS, A Journal …, 2019 - Am Psychiatric Assoc
The predisposition to neuropsychiatric disease involves a complex, polygenic, and
pleiotropic genetic architecture. However, little is known about how genetic variants impart
brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of
molecular brain-based phenotypes across five major psychiatric disorders—autism,
schizophrenia, bipolar disorder, depression, and alcoholism—compared with matched
controls. We identified patterns of shared and distinct gene-expression perturbations across …
pleiotropic genetic architecture. However, little is known about how genetic variants impart
brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of
molecular brain-based phenotypes across five major psychiatric disorders—autism,
schizophrenia, bipolar disorder, depression, and alcoholism—compared with matched
controls. We identified patterns of shared and distinct gene-expression perturbations across …
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