DNA polyplexes of a phosphorylcholine-based zwitterionic polymer for gene delivery

KM Dave, L Han, MA Jackson, L Kadlecik… - … research, 2020 - Springer
… Modulation of structure and surface chemistry have allowed … -MPC copolymers demonstrated
stable DNA condensation and … present study, we utilized PMPC-DB copolymer to form DNA

Phosphorylcholine-Grafted Molecular Bottlebrush–Doxorubicin Conjugates: High Structural Stability, Long Circulation in Blood, and Efficient Anticancer Activity

S Takano, W Islam, K Nakazawa, H Maeda… - …, 2020 - ACS Publications
… We confirmed the lack of structural transition in the PCMB between before … structure of LP
was significantly influenced by DOX conjugation and transformed from a random-coil structure

Mixed polyplex micelles with thermoresponsive and lysine-based zwitterionic shells derived from two poly (vinyl amine)-based block copolymers

R Kanto, R Yonenuma, M Yamamoto, H Furusawa… - Langmuir, 2021 - ACS Publications
… polyplexes showed the characteristic temperature-induced formation of assembled structures
in … In this study, we used novel mixed polyplex micelles from two series of cationic PVAm-…

[PDF][PDF] Study on Polyhedral Oligomeric Silsesquioxane (POSS) Methacrylate-based Copolymers for Biomedical Applications

S Chatterjee - 2019 - da.lib.kobe-u.ac.jp
… due to their ability to condense nucleic acids into their nanosized … This thesis describes
several novel application of the … ) based copolymer which formed a self-assembled structure in …

Recent advances in supramolecular block copolymers for biomedical applications

W Yasen, R Dong, A Aini, X Zhu - Journal of Materials Chemistry B, 2020 - pubs.rsc.org
… This work provided a novel strategy for achieving both … The condensation capacity of
the resulting SBC for plasmid DNA … degradation and zwitterionic phosphorylcholine based

Photoassisted Surface Modification with Zwitterionic Phosphorylcholine Polymers for the Fabrication of Ideal Biointerfaces

Y Iwasaki - Langmuir, 2023 - ACS Publications
studies on phospholipid adsorption on MPC copolymers with … molecule–induced unfolding
of the hairpin structure. Cationic … on a photolabile linker through condensation. UV (365 nm) …

Recent advances in formulation and application of molecular polymer brushes in biomedicine: Therapeutic, diagnostic, and theranostics capabilities

F Adeli, F Abbasi, P Ghandforoushan, HE Külahlı… - Nano Today, 2023 - Elsevier
… polymer assisted compaction of DNA … of MPBs and their application in novel DDSs, along
with examples of … , so that the amphiphilic graft copolymer with shorter PCL side chains …

Versatile functionalization of polysaccharides via polymer grafts: from design to biomedical applications

Y Hu, Y Li, FJ Xu - Accounts of chemical research, 2017 - ACS Publications
copolymers) were developed to study and optimize the … -, and phosphorylcholine-based
zwitterionic polymers also … a series of pseudocomb polycations as novel gene vectors by utilizing …

Zwitterionic materials for nucleic acid delivery and therapeutic applications

S He, S Liu - Journal of Controlled Release, 2024 - Elsevier
… However, some novel zwitterionic phospholipids have been … To determine the impact of
zwitterionic phosphorylcholine-based … Within the copolymer structure, PCBMA gave a zwitterionic …

Cyclen Grafted with poly[(Aspartic acid)-co-Lysine]: Preparation, Assembly with Plasmid DNA, and in Vitro Transfection Studies

C Ma, J Zhang, L Guo, C Du, P Song… - Molecular …, 2016 - ACS Publications
… , (4) developing phosphorylcholine based copolymers, (5) or … charged DNA that promotes
DNA condensation or assembly. … In the present study, the structure and composition of all title …