The COVID-19 (coronavirus disease 2019) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has led to loss of human life in millions and
devastating socio-economic consequences worldwide. The disease has created urgent
needs for intervention strategies to control the crisis and meeting these needs requires a
deep understanding of the structure-function relationships of viral proteins and relevant host
factors. The trimeric spike (S) protein of the virus decorates the viral surface and is an …