Synthesis and toxicological activity of 5-nitroindazole sulfonamides derivatives as potential antimicrobial agents. Optimization of the synthesis

C Cheptea, AC Benchea, M Găină… - 2017 E-Health and …, 2017 - ieeexplore.ieee.org
… The synthesis of new sulfonamides obtained by condensation of 5-nitroindazole with the …
, toxicological evaluation of some synthesized 5-nitroindazole sulfonamides and their potential …

Synthesis and Biological in vitro and in vivo Evaluation of 2‐(5‐Nitroindazol‐1‐yl) ethylamines and Related Compounds as Potential Therapeutic Alternatives for …

R Martín‐Escolano, B Aguilera‐Venegas… - …, 2018 - Wiley Online Library
… the antiprotozoal properties of many 5-nitroindazole derivatives, … 5-nitroindazole system, we
describe here the synthesis, … (Fe-SOD)—of some new 5-nitroindazole-derived primary (4, 6), …

[PDF][PDF] OPTIMIZATION OF THE SYNTHESIS REACTIONS OF SOME NEW THIOSEMICARBAZIDES DERIVED FROM 5-NITROINDAZOLE

C CHEPTEA, AC BENCHEA, M ZAGNAT, N BIBIRE… - FIZICĂ - cmmi.tuiasi.ro
… mechanical characterization for the new compounds. Some physico-chemical properties
of the new thiosemicarbazides derived from 5-nitroindazole were theoretically estimated by …

Antileishmanial activity of 5-nitroindazole derivatives

N Mollineda-Diogo… - Therapeutic …, 2023 - journals.sagepub.com
Derivatives of 5-nitroindazole have shown various biological and pharmacological activities
such as antiprotozoal activity. The study of the activity of indazole against trypanosomatids …

5-Nitroindazole-based compounds: further studies for activity optimization as anti-Trypanosoma cruzi agents

C Fonseca-Berzal, A Ibáñez-Escribano, S de Castro… - Acta Tropica, 2022 - Elsevier
… , a new series of eleven 5-nitroindazole derivatives (10−20) and a related 6-nitroquinazoline
(21) was synthesized and … Among these compounds, derivatives 11−14 and 17 showed …

Activity profile of two 5-nitroindazole derivatives over the moderately drug-resistant Trypanosoma cruzi Y strain (DTU TcII): in vitro and in vivo studies

C Fonseca-Berzal, CF da Silva, DGJ Batista… - Parasitology, 2020 - cambridge.org
… among several families of 5-nitroindazole derivatives. The most … Among them, 2-benzyl
derivatives were identified as the best … 5-nitroindazole derivatives were subsequently synthesized

Design, synthesis and biological evaluation of indazole–pyrimidine based derivatives as anticancer agents with anti-angiogenic and antiproliferative activities

NMY Elsayed, DA Abou El Ella, RAT Serya… - …, 2016 - pubs.rsc.org
… The synthetic route adopted to synthesize the target compounds 6a–j is … 5-nitroindazole
3 through the hydroxydiazine intermediate with the temperature kept below 25 C. 5-Nitroindazole

In vitro trichomonacidal activity and preliminary in silico chemometric studies of 5-nitroindazolin-3-one and 3-alkoxy-5-nitroindazole derivatives

A Ibanez-Escribano, JJ Nogal-Ruiz, A Gomez-Barrio… - Parasitology, 2016 - cambridge.org
… Among these compounds, 3alkoxy-5-nitroindazole derivatives 23, 24, 25 and 27 inhibited
… substitution at position 2 of the 3alkoxy-5-nitroindazole moiety (25–39) induces tumorigenic …

[HTML][HTML] 5-Nitroindazole derivatives as potential therapeutic alternatives against Acanthamoeba castellanii

R Martín-Escolano, G Pérez-Cordón, VJ Arán, C Marín… - Acta Tropica, 2022 - Elsevier
… Our results showed the effectiveness of the 5-nitroindazole derivatives tested … 5-nitroindazole
derivatives against A. castellanii trophozoites and cysts, comparing the activity of these new

[HTML][HTML] Promising hit compounds against resistant trichomoniasis: Synthesis and antiparasitic activity of 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles

A Ibáñez-Escribano, F Reviriego, N Vela… - Bioorganic & Medicinal …, 2021 - Elsevier
… In this sense, our research group has synthesized and tested a large number of …
Additionally, other 5-nitroindazole derivatives such as 1-substituted indazol-3-ols,19, 20 2-…