A reciprocal role of the Smad4-Taz axis in osteogenesis and adipogenesis of mesenchymal stem cells

JS Park, M Kim, NJ Song, JH Kim, D Seo, JH Lee… - Stem Cells, 2019 - academic.oup.com
… enhancing Taz-runt-related transcription factor 2 (Runx2) interactions in the C3H10T1/2 MSC
… may help in the artificial modulation of certain human diseases regarding osteogenic and …

[PDF][PDF] TAZ accelerates osteogenesis differentiation of mesenchymal stem cells via targeting PI3K/Akt.

FZ Tan, HL Dai - European Review for Medical & …, 2019 - europeanreview.org
TAZ, ie, a transcriptional coactivator with PDZ-binding motif, has been proven to exert … to
explore whether TAZ promotes the osteogenic differentiation of mesenchymal stem cells in the …

Pharmacological activation of TAZ enhances osteogenic differentiation and bone formation of adipose-derived stem cells

Y Zhu, Y Wu, J Cheng, Q Wang, Z Li, Y Wang… - Stem Cell Research & …, 2018 - Springer
… The transcriptional coactivator with PDZ-binding motif (TAZ) … and adipogenic differentiation
of mesenchymal stem cells. … including transcriptional factors, epigenetic modulators, and …

Polydatin improves osteogenic differentiation of human bone mesenchymal stem cells by stimulating TAZ expression via BMP2-Wnt/β-catenin signaling pathway

YS Shen, XJ Chen, SN Wuri, F Yang, FX Pang… - Stem Cell Research & …, 2020 - Springer
… of adipose-derived stem cells [21]; remarkably, TAZ … expression of RUNX2, a key transcription
factor in the BMP and Wnt/β-… whether TAZ acts as a downstream transcriptional factor of the …

Nanotopological plate stimulates osteogenic differentiation through TAZ activation

JH Hwang, DH Lee, MR Byun, AR Kim, KM Kim… - Scientific reports, 2017 - nature.com
… to regulate the differentiation of mesenchymal stem cells (MSC)… TAZ/YAP functions as a
transcriptional modulator for target gene expression. For regulation of cellular differentiation, TAZ

Snail/Slug-YAP/TAZ complexes cooperatively regulate mesenchymal stem cell function and bone formation

Y Tang, SJ Weiss - Cell Cycle, 2017 - Taylor & Francis
… /TAZ that controls the self-renewal and differentiation properties of bone marrow-derived
mesenchymal stem cells (MSCs), a cell … or TAZ that, together, control YAP/TAZ transcriptional

How is mechanobiology involved in mesenchymal stem cell differentiation toward the osteoblastic or adipogenic fate?

D Benayahu, Y Wiesenfeld… - Journal of cellular …, 2019 - Wiley Online Library
… In the nucleus, YAP and TAZ act as cofactors that interact with a range of … TAZ is a key
transcriptional modulator of MSC commitment, coactivating Runx2 and inhibiting transcriptional

Nanotopographic regulation of human mesenchymal stem cell osteogenesis

W Qian, L Gong, X Cui, Z Zhang, A Bajpai… - … applied materials & …, 2017 - ACS Publications
modulation of adhesion, cytoskeleton tension, and nuclear activation of TAZ (transcriptional
We then quantified the resultant osteogenic differentiation and nuclear TAZ of hMSCs …

The role and activation mechanism of TAZ in hierarchical microgroove/nanopore topography-mediated regulation of stem cell differentiation

P Hu, Q Gao, H Zheng, Y Tian, G Zheng… - International Journal …, 2021 - Taylor & Francis
differentiation while inhibiting adipogenic differentiation than the other two groups. The
nuclear localization and transcriptional activity of TAZ … main mechanical cues modulator, could …

Role of YAP/TAZ in cell lineage fate determination and related signaling pathways

BC Heng, X Zhang, D Aubel, Y Bai, X Li… - Frontiers in cell and …, 2020 - frontiersin.org
… signaling pathways YAP and TAZ, are transcriptional co-activator … Mesenchymal stem cell
lineage fate is known to be … , the modulation of neuronal differentiation by substrate stiffness …