The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies
N Zhao, B Di, L Xu - Cytokine & growth factor reviews, 2021 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations,
ranging from asymptomatic cases to severe pneumonia or even death. In severe COVID-19
cases, an increased level of proinflammatory cytokines has been observed in the
bloodstream, forming the so-called “cytokine storm”. Generally, nucleotide-binding
oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome …
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations,
ranging from asymptomatic cases to severe pneumonia or even death. In severe COVID-19
cases, an increased level of proinflammatory cytokines has been observed in the
bloodstream, forming the so-called “cytokine storm”. Generally, nucleotide-binding
oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome …
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