… Although the 2% of the human genome that encodes proteins has been extensively studied,
much remains to be learned about the noncoding genome and gene regulation in cancer. …

… human cell types To identify accessible chromatin regions in each of the 111 cell types, we
aggregated chromatin accessibility … We then merged these accessible chromatin regions to …

… Most single-nucleotide polymorphisms (SNPs) in the human genome occur in non-coding
and intergenic genomic regions and individually contribute small or indirect effects to complex …

… The chromatin landscape at the local level—the focus of this Review (Box 2)—is dominated
by the alternation of nucleosomes and linkers, interspersed with nucleosome-free regions …

… The development of high-throughput chromatin conformation assays (for example, Hi-C 1 …
3D organization of the human genome and how it influences gene regulation. Topologically …

… of the chromatin regulatory landscape during human early … report that the chromatin
accessibility landscape is gradually established … In the human genome, only a small percentage of …

… profiling methods may serve as an analytic foundation to identify regulatory regions, it is
reported that often less than 50% of accessible regions in human DNA are active as enhancers …

… regions that we identified spans 17% of the human genome, which is in line with recent
bulk DNase-seq profiles from fetal tissues (91). Most of these ~1 million elements are cell type–…

… chromatin landscape and its dynamics in this period remain unexplored. Here we report a
genome-wide map of accessible chromatin in … for transposase-accessible chromatin with high …

… We used human genome version hg19; mouse genome version mm10; dog … 100–200 bp)
DNA fragments. They indicate open or accessible chromatin where DNA is not tightly wrapped …