Negative effect of age, but not of latent cytomegalovirus infection on the antibody response to a novel influenza vaccine strain in healthy adults

SPH Van den Berg, A Wong, M Hendriks… - Frontiers in …, 2018 - frontiersin.org
vaccine strain to investigate the effect of age and latent CMV infection on the de novo immune
response to … impaired antibody responses to vaccination in adults with increasing age, but …

Comorbidities in the elderly and their possible influence on vaccine response

A Kwetkat, HJ Heppner - Vaccines for Older Adults: Current Practices …, 2020 - karger.com
… is associated with lower immune response of influenza vaccine [9]. … negative effects of age
and CMV on peak antibody response … concerning vaccine responses to influenza vaccination

Premature aging of the immune system affects the response to SARS-CoV-2 mRNA vaccine in β-thalassemia: role of an additional dose

R Carsetti, C Agrati, VM Pinto… - Blood, The Journal …, 2022 - ashpublications.org
… B-cell responses (Figure 1B; supplemental Figure 1B), confirming a good … immune response
of patients with TDT to SARS-CoV-2 vaccination is similar to that reported in healthy elderly

Age-associated alterations in immune function and inflammation

ED Lewis, D Wu, SN Meydani - Progress in Neuro-Psychopharmacology …, 2022 - Elsevier
Age-related changes in innate immune responses including … on age-related changes in the
immune system including … humoral immunity reduces response to vaccinations in the elderly

How can we improve the vaccination response in older people? Part II: targeting immunosenescence of adaptive immunity cells

M Garnica, A Aiello, ME Ligotti, G Accardi… - International Journal of …, 2022 - mdpi.com
… Here, we review the impact of ageing on T and B cells and … reverse the decline of the ageing
adaptive immune system. … older individuals present worse vaccine responses, this is not the …

How aging impacts vaccine efficacy: known molecular and cellular mechanisms and future directions

J Chen, JC Deng, DR Goldstein - Trends in molecular medicine, 2022 - cell.com
… have shown that aging alters the immune response to vaccination, a definitive … aging
impacts vaccine responses and highlight several current strategies to boost these responses

Remodeling of the immune response with aging: immunosenescence and its potential impact on COVID-19 immune response

LL Cunha, SF Perazzio, J Azzi, P Cravedi… - Frontiers in …, 2020 - frontiersin.org
… Enhancing the efficacy of the adaptive immune response … of immunity upon vaccination, while
inhibiting inflamm-aging will … In general, elderly individuals are less able to respond to neo-…

[HTML][HTML] Aging alters immune responses to vaccines

J Connors, EK Haddad, C Petrovas - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
… of the immune system. One effect of this change is that current vaccine strategies do not …
Aging affects the quality and quantity of antibody responses, including specificity and class …

Challenges in the Vaccination of the Elderly and Strategies for Improvement

G Soegiarto, D Purnomosari - Pathophysiology, 2023 - mdpi.com
… the immune system and vaccine response in the elderly. With … immune system in the elderly
is unable to respond normally to exposure to new antigens and vaccines, making the elderly

Effects of ageing on the immune system: infants to elderly

R Valiathan, M Ashman… - Scandinavian journal of …, 2016 - Wiley Online Library
… This decline in qualitative and quantitative level of immune responsesresponses to
vaccination and infection 7, 8. Studies indicate that, in humans, impaired immune function with age