Impact of age and vaccination history on long-term serological responses after symptomatic B. pertussis infection, a high dimensional data analysis

I van Twillert, AA Bonačić Marinović, B Kuipers… - Scientific reports, 2017 - nature.com
… Fim2/3 in unvaccinated elderly and by elevated IgG4 responses to multiple antigens only in
… pertussis vaccine (aP). This work highlights the complexity of the immune response to this re-…

The immune system and its dysregulation with aging

L Müller, S Di Benedetto, G Pawelec - … cell biology of ageing: Part II clinical …, 2019 - Springer
effects of aging on the most important components of the immune system. It considers the …
or at least contribute to the lowered responses to new pathogens and to poor vaccination

Immune system aging and the aging-related diseases in the COVID-19 era

JM Witkowski - Immunology Letters, 2022 - Elsevier
… have very successful vaccines generated using … , aging immune system loses ability to
efficiently respond to antigenic challenges, also those by the antigens included in the vaccines. …

The impact of immuno-aging on SARS-CoV-2 vaccine development

J Connors, MR Bell, J Marcy, M Kutzler, EK Haddad - Geroscience, 2021 - Springer
… the need for improved vaccine responses as part of a multifaceted approach to healthy …
the implications of aging on the innate and adaptive immune system function and explore the …

Aging in COVID-19: Vulnerability, immunity and intervention

Y Chen, SL Klein, BT Garibaldi, H Li, C Wu… - Ageing research …, 2021 - Elsevier
… Much remains to be learned about the immune responses to SARS-CoV-2 infection. We …
assessment of how aging impacts the immune response to the virus and possibly the vaccine. …

System-wide associations between DNA-methylation, gene expression, and humoral immune response to influenza vaccination

MT Zimmermann, AL Oberg, DE Grill… - PLoS …, 2016 - journals.plos.org
immune response to influenza vaccine in the elderly, we … expression, and humoral immune
response outcomes in a cohort of … the extent of immune reaction to vaccination. Unsupervised …

The cellular composition of the human immune system is shaped by age and cohabitation

EJ Carr, J Dooley, JE Garcia-Perez, V Lagou… - Nature …, 2016 - nature.com
… diseases are generally more common in women (at premenopausal ages) than in men
and that vaccine responses are more robust in women 28 , although the sex difference in …

Immunobiography and the heterogeneity of immune responses in the elderly: a focus on inflammaging and trained immunity

C Franceschi, S Salvioli, P Garagnani… - Frontiers in …, 2017 - frontiersin.org
reactions that can boost the adaptive immune responseimmunity is responsible for
non-specific effects of vaccines … that the response to vaccines, in terms of both trained immunity

Impact of age and comorbidities on SARS-CoV-2 vaccine-induced T cell immunity

LL Dietz, AK Juhl, OS Søgaard, J Reekie… - Communications …, 2023 - nature.com
… the immune system respond to SARS-CoV-2 vaccination and protect from infection and severe
disease. Two of the most predominant components of the immune system … the response of …

Maintaining a 'fit'immune system: the role of vaccines

B Laupèze, TM Doherty - Expert Review of Vaccines, 2023 - Taylor & Francis
… the evolving adaptive immune responses, and feedback from … As individuals age, their
immune system also undergoes … reduction in their ability to respond to new threats and an …