An overview of available antimalarials: discovery, mode of action and drug resistance

YQ Tang, Q Ye, H Huang… - Current Molecular …, 2020 - ingentaconnect.com
… To assist Vietnam, China provided substantial material support, including the development
and provision of antimalarial drugs for the treatment of chloroquine-resistant malaria strains …

Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria

KJ Wicht, S Mok, DA Fidock - Annual review of microbiology, 2020 - annualreviews.org
drug-resistant malaria urgently requires the development of new antimalarial drugs with
novel modes of action. … on modes of action of and mechanisms of resistance to ACT drugs. …

[HTML][HTML] Antimalarial drug resistance: an overview

HA Antony, SC Parija - Tropical parasitology, 2016 - journals.lww.com
drugs, their mechanism of action and the genetic markers validated so far for the detection of
drug-resistant … adapted from “Drug resistance in malaria”[ 23 ] and modified indicating their …

Antimalarial drug resistance: a threat to malaria elimination

D Menard, A Dondorp - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
drug resistance, the global antimalarial drug resistance … markers and mechanisms of
antimalarial drug resistance with a focus … drug-resistant malaria in the context of malaria

[PDF][PDF] Artemisinin: Tentative mechanism of action and resistance

F Torrens, L Redondo, G Castellano - Pharmaceuticals, 2017 - sciforum.net
… ) and are established for the treatment of malaria, eg., highly drugresistant strains. They
resulted in a significant advance in the treatment of malaria since the discovery and first use of …

Genomic approaches to drug resistance in malaria

F Rocamora, EA Winzeler - Annual Review of Microbiology, 2020 - annualreviews.org
mechanisms of drug action and resistance, as well as general Plasmodium biology. Insights
gleaned from such experiments will continue to prove invaluable in the exploration and …

Antimalarial drug resistance

NK Shah, N Valecha - Advances in Malaria Research, 2016 - Wiley Online Library
… However, parasite clearance is largely driven by the rapid action of artemisinin. In the
Thailand–Cambodia border, the epicenter of drugresistant malaria, parasite clearance times after …

[HTML][HTML] Drug targets for resistant malaria: historic to future perspectives

S Kumar, TR Bhardwaj, DN Prasad… - Biomedicine & …, 2018 - Elsevier
… treatment approaches for resistant malaria, new progresses, … approaches to antimalarial
drug discovery and development … promising new drugs in the future for drug resistant malaria. …

Drug resistance in Plasmodium

K Haldar, S Bhattacharjee, I Safeukui - Nature Reviews Microbiology, 2018 - nature.com
… of mass drug administration that aim to eliminate malaria. … how understanding mechanisms
of drug resistance is critical in … , risk assessment, therapy and drug development to treat both …

Mechanisms of resistance to the partner drugs of artemisinin in the malaria parasite

RE Martin, SH Shafik, SN Richards - Current opinion in pharmacology, 2018 - Elsevier
… molecular mechanisms underpinning the malaria parasite’s resistance to ACT partner drugs,
… most, of these drugs have elicited multifactorial mechanisms of resistance in P. falciparum …