Tumor-derived circulating endothelial cell clusters in colorectal cancer

I Cima, SL Kong, D Sengupta, IB Tan… - Science translational …, 2016 - science.org
… Intending to isolate CTCs from CRC patients, we instead identified clusters with both … would
respond to drugs targeting endothelial surface markers currently under clinical evaluation, …

Aneuploid circulating tumor-derived endothelial cell (CTEC): a novel versatile player in tumor neovascularization and cancer metastasis

PP Lin - Cells, 2020 - mdpi.com
… 8) CK18 + non-hematologic cells in circulation was precisely identified by iFISH to possess
a … CTECs may serve as a unique novel target en route toward developing a therapeutic …

The biology and clinical potential of circulating tumor cells

T Lozar, K Gersak, M Cemazar, CG Kuhar… - … and oncology, 2019 - sciendo.com
… in the bloodstream, extravasation and colonization are multifaceted … and receptors on cancer
cells and endothelial cells, such as … patients and represents another important step towards

Cancer-associated angiogenesis: the endothelial cell as a checkpoint for immunological patrolling

AG Solimando, SD Summa, A Vacca, D Ribatti - Cancers, 2020 - mdpi.com
… immune cells, thus inspiring several strategies aimed to target … as single cell RNA sequencing
has been used to identify diverse … , cancer immunotherapy points towards a multifaceted

Profiling circulating tumour cells and other biomarkers of invasive cancers

M Poudineh, EH Sargent, K Pantel… - Nature Biomedical …, 2018 - nature.com
towards the isolation and recovery of bulk CTCs from whole blood samples for the identification
of cells with … Most of the techniques reported to date use EpCAM as the target marker to …

Angiogenesis and Ovarian Cancer: What Potential Do Different Subtypes of Circulating Endothelial Cells Have for Clinical Application?

DB Asante, D Tierno, M Woode… - International Journal of …, 2024 - mdpi.com
… for the identification of circulating endothelial cell subtypes and their targets for therapies …
off a signalling cascade that shifts the balance towards the secretion of pro-angiogenic factors, …

Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells

L Keller, K Pantel - Nature Reviews Cancer, 2019 - nature.com
… as the detection and analysis of cells or cell products released … converge towards the possibility
of bidirectional tumour cell … CTC heterogeneity is the versatile repertoire of invasion and …

Vascular endothelial cells: heterogeneity and targeting approaches

JK Hennigs, C Matuszcak, M Trepel, J Körbelin - Cells, 2021 - mdpi.com
… As illustrated above, the endothelium is a highly versatile organ … against the most commonly
expressed EC surface markers, … instances, previously identified targeting molecules such as …

The heterogeneity of cancer endothelium: The relevance of angiogenesis and endothelial progenitor cells in cancer microenvironment

G Armani, E Pozzi, A Pagani, C Porta, M Rizzo… - Microvascular …, 2021 - Elsevier
… of cells: endothelial cells present in vessels wall, tumor cells … On the one hand, inflammation
can help the host defend against the … The “true” EPCs are now identified by ECFCs, cells that …

Targeting endothelial cell-specific molecule 1 protein in cancer: a promising therapeutic approach

H Zhang, YW Shen, LJ Zhang, JJ Chen, HT Bian… - … in Oncology, 2021 - frontiersin.org
… In this review, we discussed the multifaceted role of ESM-1 in … is a useful marker for prognosis,
which can identify those who … represent a future therapeutic target against cancer (80). …