… shown that there is an urgent requirement in the effective clinical … This review includes the
emergence of SARS-CoV-2 pneumonia … The recent discovery of new coronaviruses, and the …

… Notably, it also has 90-100% sequence homology across … , and human coronavirus HKU1
and is present in many human … The effectiveness of the drug on feline coronavirus has led to …

… coronavirus (MERS-CoV) has remained a public health concern since it first emerged in …
Cathepsin inhibition has been shown to be less efficient than TMPRSS2 inhibition in preventing …

… In 2019, SARS-CoV-2 emerged and has spread to 220 … SARS-CoV-1, it was named SARS-like
Coronavirus [40]. In order to … an effective prophylactic and/or therapeutic against COVID-…

… In 2019, the world suffered from the emergence of COVID-19 … studies have shown that
natural compounds have effective … 88% homology to SARS-like coronaviruses isolated from two …

… The newly emerged SARS-like coronavirus HCoV-EMC also has an” Achilles’ heel”: Current
effective inhibitor targeting a 3C-like protease. Protein Cell 2013, 4, 248. [CrossRef] 41. …

… surveillance studies in which several SARS-like and MERS-like … emergence of SARS-CoV
in 2003, some laboratories have … adenosine analogue with efficient inhibitory activity against …

… coronaviruses has improved substantially following previous SARS-CoV and MERS-CoV
outbreaks, in 2003 and 2012, respectively, effective … that could have appeared to influence the …

… effective therapy has been developed for CoVs infections, and the present worldwide pandemic
of corona-virus … additional interactions via hydrogen bonds appeared feasible, and iv) …

… urgent need for an effective treatment but also to decrease the … have reported in 2012 that
the emerged SARS-Like … 2c EMC/2012 (HCoV-EMC) also has an “Achilles’ heel”: a 3C-like …