Genetics, genome-wide association studies, and menarche

SF Witchel - Seminars in Reproductive Medicine, 2016 - thieme-connect.com
… to find associations between specific loci and age at menarche. It is apparent … [28] [29] [30]
Analysis of 25,970 female participants aged 16 to 98 years with … Meta-analysis of two cohorts …

Large trans-ethnic meta-analysis identifies AKR1C4 as a novel gene associated with age at menarche

C Sarnowski, DL Cousminer, N Franceschini… - Human …, 2021 - academic.oup.com
meta-analysis of AAM with half of the women being of African ancestry, we identified a new
locus … women included in the meta-analysis of genome-wide association studies of age at …

Age at menarche and age at natural menopause in East Asian women: a genome-wide association study

J Shi, B Zhang, JY Choi, YT Gao, H Li, W Lu, J Long… - Age, 2016 - Springer
… the 98 menarche loci and 5 of the 20 menopause loci … a meta-analysis of results of AM and
ANM association using data generated from the Shanghai Genome-Wide Association Studies

Genome-wide association study of age at menarche in the Taiwan Biobank suggests NOL4 as a novel associated gene

MC Tsai, CH Hsu, SK Chu, MH Roy-Gagnon… - Journal of Human …, 2023 - nature.com
… model and split-half meta-analysis method to verify our findings. … genome-wide association
studies (GWASs) among women of European ancestry revealed that at least 106 genetic loci

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

FR Day, DJ Thompson, H Helgason, DI Chasman… - Nature …, 2017 - nature.com
… women, we identify 389 independent signals (P < 5 × 10 −8 ) for age at menarche, a milestone
in … ∼7.4% of the population variance in age at menarche, corresponding to ∼25% of the …

Joint genome-wide association analyses identified 49 novel loci for age at natural menopause

L Zhang, XT Wei, JJ Niu, ZX Lin, Q Xu… - The Journal of …, 2021 - academic.oup.com
… The new loci together with previously reported loci were used … To search for additional loci,
we evaluated the meta-analysisThirty-two of these 43 loci overlap with the loci obtained from …

Joint Genome-Wide Association Study Identifies Twenty-One Novel Loci for Age at Menarche and Highlights Its Causal Association with Other Complex Diseases

GJ Feng, Q Xu, JJ Ni, SS Yang, BX Han, XT Wei… - 2021 - researchsquare.com
… study in up to 438,089 participants from 3 genome-wide association studies of … to identify
more association signals that contribute to AAM, we conduct a joint GWAS meta-analysis of …

[HTML][HTML] Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

MC Zillikens, S Demissie, YH Hsu… - Nature …, 2017 - nature.com
Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We
performed a genome-wide association study for whole body (20 cohorts of European ancestry …

Menarche—a journey into womanhood: age at menarche and health-related outcomes in East Asians

JS Chiou, YJ Lin, CYY Chang, WM Liang… - Human …, 2024 - academic.oup.com
… We performed an AAM genome-wide association study (GWAS) with 57 890 … Genome-wide
association studies (GWAS) have identified more than 400 genetic loci for age at menarche (…

Associations between age of menarche and genetic variation in women of African descent: genome-wide association study and polygenic score analysis

MS Bryan, T Ogundiran, O Ojengbede… - J Epidemiol …, 2022 - jech.bmj.com
… Of the three studies that were not included in the meta-analysis, two … . Genome-Wide
association studies in women of African ancestry identified 3q26.21 as a novel susceptibility locus