Anti-tick vaccines to prevent tick-borne diseases: an overview and a glance at the future

MJ Klouwens, JJ Trentelman… - … and prevention of …, 2016 - wageningenacademic.com
… microplus vaccine. This chapter will help to understand the rationale behind antitick vaccines
… reproduction, suggesting cell cycle proteins as possible new targets for anti-tick vaccine. …

Deciphering biological processes at the tick-host interface opens new strategies for treatment of human diseases

I Štibrániová, P Bartíková, V Holíková… - Frontiers in …, 2019 - frontiersin.org
… active compounds in tick saliva have a promising therapeutic potential for … future validation
(Maritz-Olivier et al., 2007). However, as tick anticoagulants bind specifically to their target

Exploring the Sialomes of Ticks

Y M'ghirbi - Short Views on Insect Genomics and Proteomics …, 2016 - Springer
… become an attractive target to control tick-borne diseases. … antimicrobial peptides, and
other novel human therapeutics. … The repertoire of anti-hemostatics in hard ticks which feed for …

Resistance to ticks and the path to anti-tick and transmission blocking vaccines

JG van Oosterwijk, SK Wikel - Vaccines, 2021 - mdpi.com
… saliva molecules, despite the putative therapeutic potential of some of these molecules [111]…
iron and heme metabolism proteins are potential anti-vaccine targets to disrupt tick

In vitro mode of action and anti-thrombotic activity of boophilin, a multifunctional Kunitz protease inhibitor from the midgut of a tick vector of babesiosis, Rhipicephalus …

TC Assumpcao, D Ma, DM Mizurini… - PLoS neglected …, 2016 - journals.plos.org
… of anti-hemostatics which target enzymes involved in proteolytic reactions. These molecules
are present in the salivary glands or midguts and target … of mosquitoes and ticks, and might …

Host immune responses to salivary components-a critical facet of tick-host interactions

A Ali, I Zeb, A Alouffi, H Zahid, MM Almutairi… - Frontiers in Cellular …, 2022 - frontiersin.org
tick evasion strategies at tick-host interface which is promising in the … of effective anti-tick
vaccines and drug therapeutics. … of ticks may be an interesting target for the control of ticks and …

Physiological features of blood feeding and anti-tick vaccine on tick.

T Tanaka - 2020 - cabidigitallibrary.org
… the tick to the vertebrate host. In this article, I review physiological features of tick blood
feeding and the tick-… antigens that have been identi ed for the formulation of anti-tick vaccines. …

Tick saliva and salivary glands: what do we know so far on their role in arthropod blood feeding and pathogen transmission

G Neelakanta, H Sultana - Frontiers in cellular and infection …, 2022 - frontiersin.org
… Figure 1 illustrates how anti-vector vaccines work with different tick molecules as targets.
Briefly, as ticks attaches and starts feeding, they secrete salivary molecules in saliva. In addition…

Doenitin-1: A novel Kunitz family protein with versatile functions during feeding and reproduction of the tick Haemaphysalis doenitzi

J Lu, K Wang, Z Gao, S Zhang, H Li, Y Shi… - Frontiers in Veterinary …, 2022 - frontiersin.org
… doenitzi in the hope of identifying potential vaccine candidates for tick control and future
The target PCR product was isolated by agarose gel electrophoresis (1%) and purified with gel …

Protease inhibitors in tick saliva: the role of serpins and cystatins in tick-host-pathogen interaction

J Chmelař, J Kotál, H Langhansová… - Frontiers in cellular and …, 2017 - frontiersin.org
… We also discuss the potential therapeutic use of tick protease … development of anti-tick
vaccines and tick control strategies. … proteases that are targets of tick inhibitors described in this …