… The Oncosimulator is a top-down discrete entity-discrete event model for multiscale
cancer modeling, that represents the tumor in silico as a 3D matrix of voxels and utilizes the «…

… clinical, treatment, imaging, and genomic data with models, … applied in patients with
nephroblastoma or Wilms tumor (WT) … of a patient are utilized to adjust the initial levels of the …

… , the specific application of the model to neuroblastoma cancer, and the … model represents
a promising step forward towards … in childhood cancer to better tailor treatment, adjust dosage …

… cancers have been adapted from adult oncology research. … Treatment of neuroblastoma
varies according to the stage of … 212] have helped make strides toward this goal. However, as …

… development from hyperplastic ganglia towards full-blown neuroblastoma tumors (Fig. 4D)
27 . … to prognosis in breast cancer. We tested this mRNA signature in expression data of 200 …

… concerning nephroblastoma (Wilms tumor) and breast cancer are … For multiple tools
directed toward the same disease or … For the nephroblastoma paradigm, the treatment schema …

… on cancer cells for a given treatment. In the present work a mechanistic model of cancer
response to treatment is … In the present work, several extensions and adaptations have been …

… Neuroblastoma is a complex and aggressive type of cancer that affects children. Current
treatments … It could certainly be adapted as drug resistance is a critical issue in positive patient …

… workflow, are quantitatively adapted to clinical settings since … a four-dimensional
nephroblastoma treatment model and evaluated its employment in clinical decisions making. …

… Moreover, notable improvements in colorectal cancer treatments with in silico studies and
the enhanced selectivity on specific macromolecular targets were discussed. Besides, the …