Continued great efforts have been dedicated toward high-quality trajectory generation based on optimization methods; however, most of them do not suitably and effectively consider the situation with moving obstacles; and more particularly, the future position of these moving obstacles in the presence of uncertainty within some possible prescribed prediction horizon. To cater to this rather major shortcoming, this work shows how a variational Bayesian Gaussian mixture model (vBGMM) framework can be employed to predict the future trajectory of moving obstacles; and then with this methodology, a trajectory generation framework is proposed which will efficiently and effectively address trajectory generation in the presence of moving obstacles, and incorporate the presence of uncertainty within a prediction horizon. In this work, the full predictive conditional probability density function (PDF) with mean and covariance is obtained and, thus, a future trajectory with uncertainty is formulated as a collision region represented by a confidence ellipsoid. To avoid the collision region, chance constraints are imposed to restrict the collision probability, and subsequently, a nonlinear model predictive control problem is constructed with these chance constraints. It is shown that the proposed approach is able to predict the future position of the moving obstacles effectively; and, thus, based on the environmental information of the probabilistic prediction, it is also shown that the timing of collision avoidance can be earlier than the method without prediction. The tracking error and distance to obstacles of the trajectory with prediction are smaller compared with the method without prediction.